Recent development in studies of tetrahydroprotoberberines: Mechanism in antinociception and drug addiction
文献类型：期刊论文
| 作者 | Chu, Hongyuan1; Jin, Guozhang1 ; Friedman, Eitan2; Zhen, Xuechu1
|
| 刊名 | CELLULAR AND MOLECULAR NEUROBIOLOGY
 |
| 出版日期 | 2008-06 |
| 卷号 | 28期号:4页码:491-499 |
| 关键词 | tetrahydroprotoberberines l-tetrahydropalmatine l-stepholidine dopamine receptor antinociception drug addiction |
| ISSN号 | 0272-4340 |
| DOI | 10.1007/s10571-007-9179-4 |
| 文献子类 | Article |
| 英文摘要 | The tetrahydroprotoberberines (THPBs) are compounds isolated from Chinese herbs that possess a unique pharmacological profile as D2 dopamine receptor antagonists and D1 receptor agonists. l-Tetrahydropalmatine (l-THP) and l-stepholidine (SPD), members of the THPB family, were shown to have potential clinical use in the treatment of pain. However, their mechanism of action is not clear. In the past decades, Chinese scientists have made a great deal of effort to explore the mechanisms by which the THPBs and its analogues elicit antinociception and their potential utility in treating drug abuse. It is now clear that the antinociception produced by l-THP is related to inhibition of D-2 dopamine receptors. The present review focuses on the recent progress made in understanding the mechanisms of l-THP- and l-SPD-mediated antinociception and the sequel of drug addiction. |
| WOS关键词 | CONDITIONED PLACE PREFERENCE ; DOPAMINE RECEPTOR SUBTYPES ; L-STEPHOLIDINE ; LESIONED RATS ; BRAIN ; (-)-STEPHOLIDINE ; COCAINE ; D-1 ; INVOLVEMENT ; AGONISTS |
| WOS研究方向 | Cell Biology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000255535700003 |
| 出版者 | SPRINGER/PLENUM PUBLISHERS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272903]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhen, Xuechu |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.CUNY, Dept Physiol & Pharmacol, Sch Med, New York, NY USA |
| 推荐引用方式 GB/T 7714 | Chu, Hongyuan,Jin, Guozhang,Friedman, Eitan,et al. Recent development in studies of tetrahydroprotoberberines: Mechanism in antinociception and drug addiction[J]. CELLULAR AND MOLECULAR NEUROBIOLOGY,2008,28(4):491-499. |
| APA | Chu, Hongyuan,Jin, Guozhang,Friedman, Eitan,&Zhen, Xuechu.(2008).Recent development in studies of tetrahydroprotoberberines: Mechanism in antinociception and drug addiction.CELLULAR AND MOLECULAR NEUROBIOLOGY,28(4),491-499. |
| MLA | Chu, Hongyuan,et al."Recent development in studies of tetrahydroprotoberberines: Mechanism in antinociception and drug addiction".CELLULAR AND MOLECULAR NEUROBIOLOGY 28.4(2008):491-499. |
入库方式： OAI收割
来源：上海药物研究所
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