Interactions of acetylcholinesterase with salvianolic acid B and rosmarinic acid from Salvia miltiorhiza water extract investigated by NMR relaxation rate
文献类型：期刊论文
| 作者 | Yin, GuoWei1; Li, Yi Ming2; Wei, Wei1; Jiang, Shan Hao3; Zhu, Da Yuan3; Du, Wei Hong1 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2008-06 |
| 卷号 | 19期号:6页码:747-751 |
| 关键词 | AChE inhibitors Salvianolic acid B Rosmarinic acid NMR relaxation rate |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2008.04.013 |
| 文献子类 | Article |
| 英文摘要 | In order to understand whether the ameliorating effect on old ages memory disorder by the root of Salvia miltiorhiza is related to the acetylcholinesterase (AChE) inhibition, two main ingredients, salvianolic acid B ( 1) and rosmarinic acid ( 2), which were isolated from S. miltiorhiza water extract, were investigated in vitro by NMR relaxation rate in this work. The results showed that the proton selective relaxation rates and the molecular rotational correlation time of proton pairs for compounds 1 and 2 increased significantly by adding of AChE in mixing solution. The study reveals that the two compounds might bind to the enzyme and have AChE inhibitory effect, which could contribute to the ameliorating effect at some extent on old ages memory disorder. (c) 2008 Wei Hong Du. Published by Elsevier B. V. on behalf of Chinese Chemical Society. All rights reserved. |
| WOS关键词 | HUMAN SERUM-ALBUMIN ; INHIBITORS ; H-1-NMR |
| 资助项目 | National Natural Science Foundation of China[90409015] ; National Natural Science Foundation of China[20473013] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000263668600030 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272905]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Du, Wei Hong |
| 作者单位 | 1.Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China; 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, GuoWei,Li, Yi Ming,Wei, Wei,et al. Interactions of acetylcholinesterase with salvianolic acid B and rosmarinic acid from Salvia miltiorhiza water extract investigated by NMR relaxation rate[J]. CHINESE CHEMICAL LETTERS,2008,19(6):747-751. |
| APA | Yin, GuoWei,Li, Yi Ming,Wei, Wei,Jiang, Shan Hao,Zhu, Da Yuan,&Du, Wei Hong.(2008).Interactions of acetylcholinesterase with salvianolic acid B and rosmarinic acid from Salvia miltiorhiza water extract investigated by NMR relaxation rate.CHINESE CHEMICAL LETTERS,19(6),747-751. |
| MLA | Yin, GuoWei,et al."Interactions of acetylcholinesterase with salvianolic acid B and rosmarinic acid from Salvia miltiorhiza water extract investigated by NMR relaxation rate".CHINESE CHEMICAL LETTERS 19.6(2008):747-751. |
入库方式： OAI收割
来源：上海药物研究所
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