Antitussive stemoninine alkaloids from the roots of Stemona tuberosa
文献类型：期刊论文
| 作者 | Lin, Li-Gen1; Li, Kan Man2; Tang, Chun-Ping1 ; Ke, Chang-Qiang1; Rudd, John A.2; Lin, Ge2; Ye, Yang1
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2008-06 |
| 卷号 | 71期号:6页码:1107-1110 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np070651+ |
| 文献子类 | Article |
| 英文摘要 | Investigation of the roots of Stemona tuberosa afforded five minor constituents, stemoenonine (1), 9a-0-methylstemoenonine (2), oxystemoenonine (3), 1,9a-seco-stemoenonine (4), and oxystemoninine (5), along with the known compound stemoninoamide (6). Their structures were elucidated by 1D and 2D NMR spectra and other spectroscopic studies. Alkaloids 1, 2, and 6, as well as the representative stemoninine-type alkaloid, stemoninine (7), were screened for antitussive activity in the citric acid-induced guinea pig cough model. Compounds 6 and 7 exhibited strong antitussive activity after oral and intraperitoneal administrations. |
| WOS关键词 | MODELS ; COUGH |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000257227200040 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272909]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ye, Yang |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Chinese Univ Hong Kong, Dept Pharmacol, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Li-Gen,Li, Kan Man,Tang, Chun-Ping,et al. Antitussive stemoninine alkaloids from the roots of Stemona tuberosa[J]. JOURNAL OF NATURAL PRODUCTS,2008,71(6):1107-1110. |
| APA | Lin, Li-Gen.,Li, Kan Man.,Tang, Chun-Ping.,Ke, Chang-Qiang.,Rudd, John A..,...&Ye, Yang.(2008).Antitussive stemoninine alkaloids from the roots of Stemona tuberosa.JOURNAL OF NATURAL PRODUCTS,71(6),1107-1110. |
| MLA | Lin, Li-Gen,et al."Antitussive stemoninine alkaloids from the roots of Stemona tuberosa".JOURNAL OF NATURAL PRODUCTS 71.6(2008):1107-1110. |
入库方式： OAI收割
来源：上海药物研究所
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