Microwave-assisted efficient and convenient synthesis of 2,4(1H,3H)-quinazolinediones and 2-thioxoquinazolines
文献类型：期刊论文
| 作者 | Li, Zhaoguang1,2; Huang, He1; Sun, Hongbin2; Hang, Hualiang1,3; Liu, Hong1
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| 刊名 | JOURNAL OF COMBINATORIAL CHEMISTRY
 |
| 出版日期 | 2008-05 |
| 卷号 | 10期号:3页码:484-486 |
| ISSN号 | 1520-4766 |
| DOI | 10.1021/cc800040z |
| 文献子类 | Article |
| 英文摘要 | An efficient and convenient method was developed for the preparation of 2,4(1H,3H)-quinazolinediones and 2-thioxoquinazolinones. Substituted methyl anthranilate reacted with various iso(thio)cyanates in DMSO/H(2)O without any catalyst or base by using microwave irradiation to generate diversity on the 2,4(1H,3H)-quinazolinediones or 2-thioxoquinazolinones. A variety of substrates can participate in the process with good yields and high purities, making this methodology suitable for library synthesis in drug discovery efforts. |
| WOS关键词 | DERIVATIVES ; INHIBITORS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000255848700023 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272929]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res,Drug Discovery & Design Ct, Shanghai 201203, Peoples R China; 2.China Pharmaceut Univ, Ctr Drug Discovery, Coll Pharm, Nanjing 210009, Peoples R China; 3.E China Univ Sci & Technol, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhaoguang,Huang, He,Sun, Hongbin,et al. Microwave-assisted efficient and convenient synthesis of 2,4(1H,3H)-quinazolinediones and 2-thioxoquinazolines[J]. JOURNAL OF COMBINATORIAL CHEMISTRY,2008,10(3):484-486. |
| APA | Li, Zhaoguang,Huang, He,Sun, Hongbin,Hang, Hualiang,&Liu, Hong.(2008).Microwave-assisted efficient and convenient synthesis of 2,4(1H,3H)-quinazolinediones and 2-thioxoquinazolines.JOURNAL OF COMBINATORIAL CHEMISTRY,10(3),484-486. |
| MLA | Li, Zhaoguang,et al."Microwave-assisted efficient and convenient synthesis of 2,4(1H,3H)-quinazolinediones and 2-thioxoquinazolines".JOURNAL OF COMBINATORIAL CHEMISTRY 10.3(2008):484-486. |
入库方式： OAI收割
来源：上海药物研究所
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