The new water-soluble artemisinin derivative SM905 ameliorates collagen-induced arthritis by suppression of inflammatory and Th17 responses
文献类型：期刊论文
| 作者 | Wang, J-X1; Tang, W.1 ; Zhou, R.1; Wan, J.1; Shi, L-P1; Zhang, Y.2; Yang, Y-F1; Li, Y.2; Zuo, J-P1
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| 刊名 | BRITISH JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2008-03 |
| 卷号 | 153期号:6页码:1303-1310 |
| 关键词 | artemisinin derivative SM905 collagen-induced arthritis T cell inflammation Th17 |
| ISSN号 | 0007-1188 |
| DOI | 10.1038/bjp.2008.11 |
| 文献子类 | Article |
| 英文摘要 | Background and purpose: Our previous study showed that SM905, a novel artemisinin derivative, exhibited potent immunosuppressive activity. In this study, we evaluate preventive and therapeutic effect of SM905 on collagen-induced arthritis (CIA) in DBA/1 mice, and investigate its mechanisms both in inflammatory and autoimmune aspects of the disease. Experimental approach: CIA was induced by type II bovine collagen (CII) in DBA/1 mice. SM905 was given orally either before (continuously 1 day before booster immunization) or after disease onset (continuously 14 days after booster immunization). Disease incidence and severity were monitored, mRNA expression of proinflammatory mediators was determined by real-time PCR, purified T cell proliferation was assessed using [H-3]-thymidine incorporated assay, and T helper (Th) 17/Th1/Th2 type cytokine production was examined by ELISA. Key results: Oral treatment with SM905 delayed disease onset, reduced arthritis incidence and severity, and suppressed the enhanced expression of pro-inflammatory cytokines, chemokines and chemokine receptors in draining lymph nodes. The CII-induced T cell proliferation and production of interleukin (IL)-17A by T cells were strikingly inhibited. Correspondingly, the mRNA expression of IL-17A and ROR gamma t (a specific transcription factor for Th17) was also reduced. This effect was coupled with a striking reduction of IL-6 production, which has a critical role in Th17 development. In established arthritis, SM905 profoundly inhibited disease progression, reduced IL-17A and RORgt mRNA expression, and suppressed pro-inflammatory mediator expression in arthritic joints. Conclusions and implications: SM905 had beneficial effects on CIA by suppressing inflammatory and pathogenic Th17 responses. |
| WOS关键词 | EXPERIMENTAL RHEUMATOID-ARTHRITIS ; T-CELL-ACTIVATION ; IMMUNOSUPPRESSIVE ACTIVITY ; IN-VIVO ; CYTOKINE PATHWAYS ; PROLIFERATION ; AUTOIMMUNITY ; ARTEMETHER ; ESTERS ; VITRO |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000254042500026 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272963]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第一研究室 |
| 通讯作者 | Zuo, J-P |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Dept Pharmacol 1, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Dept Synthet Chem, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, J-X,Tang, W.,Zhou, R.,et al. The new water-soluble artemisinin derivative SM905 ameliorates collagen-induced arthritis by suppression of inflammatory and Th17 responses[J]. BRITISH JOURNAL OF PHARMACOLOGY,2008,153(6):1303-1310. |
| APA | Wang, J-X.,Tang, W..,Zhou, R..,Wan, J..,Shi, L-P.,...&Zuo, J-P.(2008).The new water-soluble artemisinin derivative SM905 ameliorates collagen-induced arthritis by suppression of inflammatory and Th17 responses.BRITISH JOURNAL OF PHARMACOLOGY,153(6),1303-1310. |
| MLA | Wang, J-X,et al."The new water-soluble artemisinin derivative SM905 ameliorates collagen-induced arthritis by suppression of inflammatory and Th17 responses".BRITISH JOURNAL OF PHARMACOLOGY 153.6(2008):1303-1310. |
入库方式： OAI收割
来源：上海药物研究所
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