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Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway
文献类型：期刊论文
| 作者 | Tan, Min-Jia2 ; Ye, Ji-Ming1; Turner, Nigel1; Hohnen-Behrens, Cordula1; Ke, Chang-Qiang2; Tang, Chun-Ping2; Chen, Tong2; Weiss, Hans-Christoph3; Gesing, Ernst-Rudolf4; Rowland, Alex1
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| 刊名 | CHEMISTRY & BIOLOGY
 |
| 出版日期 | 2008-03 |
| 卷号 | 15期号:3页码:263-273 |
| ISSN号 | 1074-5521 |
| DOI | 10.1016/j.chembiol.2008.01.013 |
| 文献子类 | Article |
| 英文摘要 | Four cucurbitane glycosides, momordicosides Q, R, S, and T, and stereochemistry-established karaviloside XI, were isolated from the vegetable bitter melon (Momordica charantia). These compounds and their aglycones exhibited a number of biologic effects beneficial to diabetes and obesity. In both L6 myotubes and 3T3-L1 adipocytes, they stimulated GLUT4 translocation to the cell membrane-an essential step for inducible glucose entry into cells. This was associated with increased activity of AM P-activated protein kinase (AMPK), a key pathway mediating glucose uptake and fatty acid oxidation. Furthermore, momordicoside(s) enhanced fatty acid oxidation and glucose disposal during glucose tolerance tests in both insulin-sensitive and insulin-resistant mice. These findings indicate that cucurbitane triterpenoids, the characteristic constituents of M. charantia, may provide leads as a class of therapeutics for diabetes and obesity. |
| WOS关键词 | MOMORDICA-CHARANTIA L ; CUCURBITANE-TYPE TRITERPENES ; PROTEIN-KINASE ; IMMATURE FRUITS ; DRUG DISCOVERY ; INSULIN ACTION ; GLYCOSIDES ; CONSTITUENTS ; METFORMIN ; MECHANISM |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000254570500012 |
| 出版者 | CELL PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272964]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 化学蛋白质组学研究中心 |
| 通讯作者 | James, David E. |
| 作者单位 | 1.Univ New S Wales, Garvan Inst Med Res, Diabet & Obes Res Program, Sydney, NSW 2010, Australia; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key lab Drug Res, Shanghai 201203, Peoples R China; 3.Bayer Ind Serv GmbH & Co, D-51368 Leverkusen, Germany; 4.Bayer CropSci AG, R&D, Ctr Agr, D-40789 Monheim, Germany |
| 推荐引用方式 GB/T 7714 | Tan, Min-Jia,Ye, Ji-Ming,Turner, Nigel,et al. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway[J]. CHEMISTRY & BIOLOGY,2008,15(3):263-273. |
| APA | Tan, Min-Jia.,Ye, Ji-Ming.,Turner, Nigel.,Hohnen-Behrens, Cordula.,Ke, Chang-Qiang.,...&Ye, Yang.(2008).Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway.CHEMISTRY & BIOLOGY,15(3),263-273. |
| MLA | Tan, Min-Jia,et al."Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway".CHEMISTRY & BIOLOGY 15.3(2008):263-273. |
入库方式： OAI收割
来源：上海药物研究所
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