Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappa B pathway
文献类型：期刊论文
| 作者 | Ruan Min1; Ji Tong1; Yang Wenjun1; Duan Wenhu2 ; Zhou Xiaojian1; He Jiacai3; Zhou Jian3; Chen Wantao1; Zhang Chenping1
|
| 刊名 | PHYTOTHERAPY RESEARCH
 |
| 出版日期 | 2008-03 |
| 卷号 | 22期号:3页码:407-415 |
| 关键词 | Shikonin oral squamous cell carcinoma (OSCC) growth inhibition apoptosis NF-kappa B caspase family |
| ISSN号 | 0951-418X |
| DOI | 10.1002/ptr.2340 |
| 文献子类 | Article |
| 英文摘要 | Shikonin, a naphthoquinone pigment isolated from the Chinese herbal therapeutic, Zicao, has been shown to exhibit antioxidant and anticancer effects. In this study, its ability to induce apoptosis in cultured Tca-8113 oral cancer cells was studied. Treatment of the Tca-8113 cells with a variety of concentrations of Shikonin (1040 gm) resulted in dose- and time-dependent sequences of events marked by apoptosis, as shown by the loss of cell viability, chromatin condensation, internucleosomal DNA fragmentation and sub-G1 phase accumulation. Furthermore, apoptosis in the Tca-8113 cells was accompanied by the activation of protease caspase-8, -9, -3 and low expression of Bcl-2 protein. Interestingly, inactivation of the NF-kappa B pathway was found in shikonin-induced apoptosis in Tca-8113 cells. These results raise the possibility that the anti-tumor effects of Shikonin in Tca-8113 cells are at least partly through the inactivation of the NF-kappa B pathway and subsequent activation of protease caspase family. Pharmacological inhibition of the NF-kappa B activity by Shikonin might be a powerful treatment option for OSCC in which activation of NF-kappa B plays a critical role in tumor growth and progression. Copyright (C) 2007 John Wiley & Sons, Ltd. |
| WOS关键词 | NATURAL-PRODUCTS ; CANCER STATISTICS ; GENE-EXPRESSION ; BCL-2 FAMILY ; TUMOR-GROWTH ; ACTIVATION ; ANGIOGENESIS ; SURVIVAL ; THERAPY ; ALPHA |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000254481000023 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272969]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhang Chenping |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Coll Med, Dept Oral & Maxillofacial Surg, Affiliated Peoples Hosp 9, Shanghai 200011, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, SIBS, State Key Lab Drug Res, Shanghai 200031, Peoples R China; 3.Anhui Med Univ, Coll Stomatol, Dept Oral & Maxillofacial Surg, Hefei 230032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ruan Min,Ji Tong,Yang Wenjun,et al. Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappa B pathway[J]. PHYTOTHERAPY RESEARCH,2008,22(3):407-415. |
| APA | Ruan Min.,Ji Tong.,Yang Wenjun.,Duan Wenhu.,Zhou Xiaojian.,...&Zhang Chenping.(2008).Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappa B pathway.PHYTOTHERAPY RESEARCH,22(3),407-415. |
| MLA | Ruan Min,et al."Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappa B pathway".PHYTOTHERAPY RESEARCH 22.3(2008):407-415. |
入库方式： OAI收割
来源：上海药物研究所
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