Pharmacokinetics and metabolism of lithospermic acid by LC/MS/MS in rats
文献类型：期刊论文
| 作者 | Wang, Li1,2; Zhang, Qiang1; Li, Xiaochuan1; Lu, Youli1; Xue, Zhimou2; Xuan, Lijiang1 ; Wang, Yiping1
|
| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2008-02-28 |
| 卷号 | 350期号:1-2页码:240-246 |
| 关键词 | lithospermic acid pharmacokinetics metabolism rat bile LC/MS/MS |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2007.09.001 |
| 文献子类 | Article |
| 英文摘要 | The pharmacokinetics and metabolism of lithospermic acid (LA), a component isolated from Salvia miltiorrhiza, and its two O-methylated metabolites (3'-monomethyl- and 3',3 ''-dimethyl-lithospermic acid), were analyzed by a rapid and specific isocratic liquid chromatography-tandem mass spectrometry (LC/MS/MS) method. Rat serum samples collected after intravenous and oral administration were analyzed for obtaining pharmacokinetic data of LA. Two O-methylated metabolites, namely one 3'-monomethyl- and one 3',3 ''-dimethyl-lithospermic acid were detected in rat serum and bile samples after intravenous and oral administration of LA, respectively. An oral bioavailability of 1.15% was found, with the AUC(0-t) values of 301.89 and 3.46 mg h/L for intravenous and oral administration, respectively. The total recovery from bile was 75.36% (0.46% for LA, 17.23% for M1, and 57.67% for M2) after intravenous administration, and 4.26% (0.00% for LA, 0.10% for Ml, and 4.16% for M2) after oral administration. These results indicate that methylation is the main metabolic pathway of LA, and that LA is excreted into rat bile and finally into feces. (c) 2007 Elsevier B.V. All rights reserved. |
| WOS关键词 | SALVIA-MILTIORRHIZA ; POLYPHENOLIC ACIDS ; ROSMARINIC ACID ; INHIBITION ; OLIGOMERS ; RUDERALE ; PLANTS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000253504100029 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272972]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Yiping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Soochow Univ, Sch Life Sci, Suzhou 215006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Li,Zhang, Qiang,Li, Xiaochuan,et al. Pharmacokinetics and metabolism of lithospermic acid by LC/MS/MS in rats[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2008,350(1-2):240-246. |
| APA | Wang, Li.,Zhang, Qiang.,Li, Xiaochuan.,Lu, Youli.,Xue, Zhimou.,...&Wang, Yiping.(2008).Pharmacokinetics and metabolism of lithospermic acid by LC/MS/MS in rats.INTERNATIONAL JOURNAL OF PHARMACEUTICS,350(1-2),240-246. |
| MLA | Wang, Li,et al."Pharmacokinetics and metabolism of lithospermic acid by LC/MS/MS in rats".INTERNATIONAL JOURNAL OF PHARMACEUTICS 350.1-2(2008):240-246. |
入库方式： OAI收割
来源：上海药物研究所
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