Chlorahololides C-F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius
文献类型：期刊论文
| 作者 | Yang, Sheng-Ping; Gao, Zhao-Bing ; Wu, Yan; Hu, Guo-Yuan; Yue, Jian-Min
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2008-02-25 |
| 卷号 | 64期号:9页码:2027-2034 |
| 关键词 | chlorahololides C-F potassium channel blocker structural elucidation Chloranthus holostegius |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2007.12.057 |
| 文献子类 | Article |
| 英文摘要 | Four unusually fused polycyclic sesquiterpenoid dimers, chlorahololides C - F (1 - 4), were isolated from the whole plant of Chloranthus holostegius. Their structures and absolute configurations were established by spectroscopic methods, including 2D NMR and CD spectra. Chlorahololides C - F (1 - 4) exerted potent and selective inhibition on the delayed rectifier (I(K)) K(+) current with the IC(50) values of 3.6 +/- 10.1, 2.7 +/- 0.3, 27.5 +/- 5.1. and 57.5 +/- 6.1 mu M, respectively. (c) 2008 Elsevier Ltd. All rights reserved. |
| WOS关键词 | 2-IODOMELATONIN PREVENTS APOPTOSIS ; CEREBELLAR GRANULE NEURONS ; CHEMICAL-CONSTITUENTS ; EUPATORIUM-CHINENSE ; K+ CURRENT ; JAPONICUS ; PLANTS ; SESQUITERPENOIDS ; LINDENANOLIDES ; INHIBITION |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000253515100002 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272975]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Sheng-Ping,Gao, Zhao-Bing,Wu, Yan,et al. Chlorahololides C-F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius[J]. TETRAHEDRON,2008,64(9):2027-2034. |
| APA | Yang, Sheng-Ping,Gao, Zhao-Bing,Wu, Yan,Hu, Guo-Yuan,&Yue, Jian-Min.(2008).Chlorahololides C-F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius.TETRAHEDRON,64(9),2027-2034. |
| MLA | Yang, Sheng-Ping,et al."Chlorahololides C-F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius".TETRAHEDRON 64.9(2008):2027-2034. |
入库方式： OAI收割
来源：上海药物研究所
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