Structural studies on an unusual novel macrocyclic polydisulfide from the Chinese mangrove Bruguiera gymnorrhiza
文献类型：期刊论文
| 作者 | Liu Hai-Li; Shen Xu ; Jiang Hua-Liang; Guo Yue-Wei
|
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2008-02 |
| 卷号 | 28期号:2页码:246-251 |
| 关键词 | Bruguiera gymnorrhiza macrocyclic polydisulfide neogymnorrhizol gymnorrhizol hPTP1B inhibitory activity |
| ISSN号 | 0253-2786 |
| 文献子类 | Article |
| 英文摘要 | Chemical study on the mangrove Bruguiera gymnorrhiza collected from Zhanjiang has resulted in the isolation of an unusual novel macrocyclic polydisulfide, neogymnorrhizol (1), which possesses an unprecedented carbon skeleton characterized by a twenty-membered macrocycle that is composed of four repeated 1,3-dimercaptopropan-2-ol units, along with four known related compounds. The structure of the new compound 1 was determined by detailed spectroscopic data analysis (IR, H-1 NMR, C-13 NMR, 2D NMR, MS, etc.). The known compounds, namely gymnorrhizol (2a), bruguiesulfurol (3), brugierol (4) and isobrugierol (5), were determined by either an X-ray diffraction analysis or comparison with the data reported in the literatures. A plausible biogenetic origin of these uncommon polydisulfides and their biogenetic relationship were also discussed. In bioassay, compounds 2a and 3 exhibited significant hPTP1B inhibitory activity. |
| WOS关键词 | EXCOECARIA-AGALLOCHA-L ; CRYSTAL-STRUCTURE ; DISULFIDES ; 1,2-DITHIOLANE ; SPORIDESMINS ; DITERPENES ; ALKALOIDS ; SEXANGULA |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3229845 |
| WOS记录号 | WOS:000254112800011 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272992]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu Hai-Li |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu Hai-Li,Shen Xu,Jiang Hua-Liang,et al. Structural studies on an unusual novel macrocyclic polydisulfide from the Chinese mangrove Bruguiera gymnorrhiza[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2008,28(2):246-251. |
| APA | Liu Hai-Li,Shen Xu,Jiang Hua-Liang,&Guo Yue-Wei.(2008).Structural studies on an unusual novel macrocyclic polydisulfide from the Chinese mangrove Bruguiera gymnorrhiza.CHINESE JOURNAL OF ORGANIC CHEMISTRY,28(2),246-251. |
| MLA | Liu Hai-Li,et al."Structural studies on an unusual novel macrocyclic polydisulfide from the Chinese mangrove Bruguiera gymnorrhiza".CHINESE JOURNAL OF ORGANIC CHEMISTRY 28.2(2008):246-251. |
入库方式： OAI收割
来源：上海药物研究所
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