Huperzine a reverses cholinergic and monoaminergic dysfunction induced by bilateral nucleus basalis magnocellularis injection of beta-amyloid peptide (1-40) in rats
文献类型：期刊论文
| 作者 | Liang, Yan Qi; Huang, Xiao Tian; Tang, Xi Can |
| 刊名 | CELLULAR AND MOLECULAR NEUROBIOLOGY
 |
| 出版日期 | 2008-01 |
| 卷号 | 28期号:1页码:87-101 |
| 关键词 | huperzine A Alzheimer's disease monoaminergic dysfunction beta-Amyloid peptide nucleus basalis magnocellularis |
| ISSN号 | 0272-4340 |
| DOI | 10.1007/s10571-007-9158-9 |
| 文献子类 | Article |
| 英文摘要 | (1) Huperzine A, a promising therapeutic agent for Alzheimer's disease (AD), was tested for its effects on cholinergic and monoaminergic dysfunction induced by injecting beta-amyloid peptide-(1 - 40) into nucleus basalis magnocellularis of the rat. (2) Bilateral injection of 10 mu g beta-amyloid peptide-(1 - 40) into nucleus basalis magnocellularis produced local deposits of amyloid plaque and functional abnormalities detected by microdialysis. In medial prefrontal cortex, reductions in the basal levels and stimulated release of acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine were observed. However, oral huperzine A (0.18 mg/kg, once daily for 21 consecutive days) markedly reduced morphologic abnormalities at the injection site in rats infused with beta-amyloid peptide-(1 - 40). Likewise, this treatment ameliorated the beta-amyloid peptide-(1 - 40)-induced deficits in extracellular acetylcholine, dopamine, and norepinephrine (though not 5-hydroxytryptamine) in medial prefrontal cortex, and lessened the reduction in nicotine or methoctramine-stimulated release of acetylcholine and K+-evoked releases of acetylcholine and dopamine. (3) The present results provide the first direct evidence that huperzine A acts to oppose neurotoxic effects of beta-amyloid peptide on cholinergic, dopaminergic, and noradrenergic systems of the rat forebrain. |
| WOS关键词 | ALZHEIMERS-DISEASE ; INFUSED RATS ; BRAIN ; NEUROTOXICITY ; NEURONS ; PROTEIN ; FOREBRAIN ; SYSTEMS ; NOREPINEPHRINE ; ACETYLCHOLINE |
| WOS研究方向 | Cell Biology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000253191800011 |
| 出版者 | SPRINGER/PLENUM PUBLISHERS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273010]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Tang, Xi Can |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Yan Qi,Huang, Xiao Tian,Tang, Xi Can. Huperzine a reverses cholinergic and monoaminergic dysfunction induced by bilateral nucleus basalis magnocellularis injection of beta-amyloid peptide (1-40) in rats[J]. CELLULAR AND MOLECULAR NEUROBIOLOGY,2008,28(1):87-101. |
| APA | Liang, Yan Qi,Huang, Xiao Tian,&Tang, Xi Can.(2008).Huperzine a reverses cholinergic and monoaminergic dysfunction induced by bilateral nucleus basalis magnocellularis injection of beta-amyloid peptide (1-40) in rats.CELLULAR AND MOLECULAR NEUROBIOLOGY,28(1),87-101. |
| MLA | Liang, Yan Qi,et al."Huperzine a reverses cholinergic and monoaminergic dysfunction induced by bilateral nucleus basalis magnocellularis injection of beta-amyloid peptide (1-40) in rats".CELLULAR AND MOLECULAR NEUROBIOLOGY 28.1(2008):87-101. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。