Farnesoid X receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter
文献类型：期刊论文
| 作者 | Shen, Hong; Zhang, Yu; Ding, Hong ; Wang, Xu; Chen, Lili; Jiang, Hualiang; Shen, Xu
|
| 刊名 | CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
 |
| 出版日期 | 2008 |
| 卷号 | 22期号:1-4页码:1-14 |
| 关键词 | farnesoid X receptor glucose transporter 4 type 2 diabetes glucose metabolism |
| ISSN号 | 1015-8987 |
| DOI | 10.1159/000149779 |
| 文献子类 | Article |
| 英文摘要 | GLUT4, the main insulin-responsive glucose transporter, plays a critical role in maintaining systemic glucose homeostasis and is subject to complicated metabolic regulation. GLUT4 expression disorder might cause insulin resistance, and over-expression of GLUT4 has been confirmed to ameliorate diabetes. Here, we reported that farnesoid X receptor (FXR) and its agonist chenodeoxycholic acid (CDCA) could induce GLUT4 transcription in 3T3-L1 and HepG2 cells. Furthermore, CDCA could increase the GLUT4 protein amount in C57BL/6J mice sex-dependently. The following progressive 5'-deletion analysis and site-mutation investigation further suggested that FXR could induce GLUT4 expression through FXR response element (FXRE) in the GLUT4 promoter. EMSA and knock-down of retinoid X receptor (RXR) indicated that FXR binds to the GLUT4-FXRE as a monomer and RXR does not participate in the FXR stimulation of GLUT4 expression. In addition, we demonstrated that FXR does not interfere with insulin-induced GLUT4 translocation to plasma membrane. All these data thereby implied that FXR is a new transcription factor of GLUT4, further elucidating the potential role for FXR in glucose metabolism. Copyright (C) 2008 S. Karger AG, Basel. |
| WOS关键词 | GLUCOSE-TRANSPORTER GLUT4 ; ACTIVATED RECEPTOR ; INSULIN-RESISTANCE ; GENE-EXPRESSION ; BILE-ACIDS ; 3T3-L1 ADIPOCYTES ; TRANSGENIC MICE ; TRANSCRIPTIONAL REGULATION ; DIABETES-MELLITUS ; NUCLEAR RECEPTORS |
| WOS研究方向 | Cell Biology ; Physiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000258317900001 |
| 出版者 | KARGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273011]  |
| 专题 | 药理学第三研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Shen, Xu |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Hong,Zhang, Yu,Ding, Hong,et al. Farnesoid X receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter[J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2008,22(1-4):1-14. |
| APA | Shen, Hong.,Zhang, Yu.,Ding, Hong.,Wang, Xu.,Chen, Lili.,...&Shen, Xu.(2008).Farnesoid X receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter.CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,22(1-4),1-14. |
| MLA | Shen, Hong,et al."Farnesoid X receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter".CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 22.1-4(2008):1-14. |
入库方式： OAI收割
来源：上海药物研究所
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