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Water-soluble constituents of the root barks of Fraxinus rhynchophylla (Chinese drug Qinpi)

文献类型：期刊论文

作者Xiao, Kai1,2; Song, Qing-Hong1; Zhang, Shu-Wei1; Xuan, Li-Jiang1
刊名JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
出版日期2008
卷号10期号:2页码:205-210
关键词Fraxinus rhynchophylla Oleaceae fraxisecoside PTP1B inhibition activity
ISSN号1028-6020
DOI10.1080/10286020701394514
文献子类Article
英文摘要Chemical studies on the roots of Fraxinus rhynchophylla led to the isolation of fraxisecoside (1), a novel coumarin-secoiridoid hybrid glycoside, namely, fraxetin-8-O-[11'-methyl-oleosidyl-(7' -> 6 '')]-beta-Dglucopyranoside and 14 known compounds. Their structures were elucidated based on chemical evidence and spectroscopic analysis, including extensive 2D NMR methods. Compound 2 was first isolated as a pure compound. Compound 1 exhibited moderate PTP1B inhibition activity. Compounds 1 and 2 showed inhibition activity against B- and T-cell proliferation, without cytotoxicity.
WOS关键词SECOIRIDOID GLUCOSIDES ; GLYCOSIDES
WOS研究方向Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000256384400015
出版者TAYLOR & FRANCIS LTD
源URL[http://119.78.100.183/handle/2S10ELR8/273048]  
专题上海中药现代化研究中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Xuan, Li-Jiang
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Second Mil Med Univ, Fac Naval Med, Lab Toxin & Pharmarmacol, Shanghai 200433, Peoples R China
推荐引用方式
GB/T 7714		 Xiao, Kai,Song, Qing-Hong,Zhang, Shu-Wei,et al. Water-soluble constituents of the root barks of Fraxinus rhynchophylla (Chinese drug Qinpi)[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2008,10(2):205-210.
APA Xiao, Kai,Song, Qing-Hong,Zhang, Shu-Wei,&Xuan, Li-Jiang.(2008).Water-soluble constituents of the root barks of Fraxinus rhynchophylla (Chinese drug Qinpi).JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,10(2),205-210.
MLA Xiao, Kai,et al."Water-soluble constituents of the root barks of Fraxinus rhynchophylla (Chinese drug Qinpi)".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 10.2(2008):205-210.

入库方式： OAI收割

来源：上海药物研究所

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