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Discovering potential drug leads via docking, synthesis and bioassay

文献类型：期刊论文

作者Ye Deju2; Luo Xiaomin2; Shen Jianhua2; Zhu Weiliang2; Shen Xu1,2; Jiang Hualiang1,2; Liu Hong2
刊名PROGRESS IN CHEMISTRY
出版日期2007-12
卷号19期号:12页码:1939-1946
关键词drug leads virtual screening molecular docking synthesis bioassay
ISSN号1005-281X
文献子类Article
英文摘要Discovering potential drug leads has played a key role in the drug development. As a new method or technology for drug discovery, virtual screening via molecular docking has been developed as a practical tool complemented to high throughput empirical screening, and is now a widespread drug lead identification method in the pharmaceutical industry. In this review, we introduce recent advances in discovering drug leads via docking, synthesis and bioassay focused on our research.
WOS关键词HUMAN CYCLOPHILIN-A ; POTASSIUM CHANNEL BLOCKERS ; STRUCTURE-BASED DESIGN ; MOLECULAR DOCKING ; ELECTROPHYSIOLOGICAL ASSAY ; BIOLOGICAL EVALUATION ; CHEMICAL INHIBITORS ; 3C-LIKE PROTEINASE ; FLEXIBLE DOCKING ; NATURAL-PRODUCTS
WOS研究方向Chemistry
语种中文
CSCD记录号CSCD:3050915
WOS记录号WOS:000251957400012
出版者CHINESE ACAD SCIENCES
源URL[http://119.78.100.183/handle/2S10ELR8/273110]  
专题药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
药物发现与设计中心
通讯作者Ye Deju
作者单位1.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med,State Key Lab Drug Res, Ctr Drug Discovery & Design, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Ye Deju,Luo Xiaomin,Shen Jianhua,et al. Discovering potential drug leads via docking, synthesis and bioassay[J]. PROGRESS IN CHEMISTRY,2007,19(12):1939-1946.
APA Ye Deju.,Luo Xiaomin.,Shen Jianhua.,Zhu Weiliang.,Shen Xu.,...&Liu Hong.(2007).Discovering potential drug leads via docking, synthesis and bioassay.PROGRESS IN CHEMISTRY,19(12),1939-1946.
MLA Ye Deju,et al."Discovering potential drug leads via docking, synthesis and bioassay".PROGRESS IN CHEMISTRY 19.12(2007):1939-1946.

入库方式： OAI收割

来源：上海药物研究所

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