Structure elucidation and sulfated derivatives preparation of two alpha-D-glucans from Gastrodia elata Bl. and their anti-dengue virus bioactivities
文献类型：期刊论文
| 作者 | Qiu, Hong; Tang, Wei ; Tong, Xiankun; Ding, Kan; Zuo, Jianping
|
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2007-11-05 |
| 卷号 | 342期号:15页码:2230-2236 |
| 关键词 | Gastrodia elata alpha-D-glucan dengue virus sulfated polysaccharide |
| ISSN号 | 0008-6215 |
| DOI | 10.1016/j.carres.2007.06.021 |
| 文献子类 | Article |
| 英文摘要 | The structures of two glucans, WGEW and AGEW, isolated from Gastrodia elata Bl. were elucidated using monosaccharide composition analysis by gas chromatography (GC), methylation analysis by gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR) spectroscopy. Their structures were deduced as an alpha-D-(1 --> 4)-glucan with an alpha-(1 --> 4) linked branch attached to O-6 branch points with different branch degrees. Their sulfate derivatives with distinct degrees of substitution (DS) were prepared. The substitution position was assigned to O-6 according to the C-13 NMR spectra. All sulfated derivatives showed strong anti-dengue virus bioactivities. The structure-activity relationships (SAR) between the polysaccharides and their sulfated derivatives were also investigated. Results showed that the higher the DS is, the more potent the impact on the dengue virus infection would be. (C) 2007 Elsevier Ltd. All rights reserved. |
| WOS关键词 | COLORIMETRIC ASSAY ; HEPARAN-SULFATE ; POLYSACCHARIDES ; CELL ; SEROTYPE ; AGENTS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000249859000009 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273115]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ding, Kan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Materia Med, Glycobiol & Glycochem Lab,State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Materia Med, Lab Immunopharmacol,State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiu, Hong,Tang, Wei,Tong, Xiankun,et al. Structure elucidation and sulfated derivatives preparation of two alpha-D-glucans from Gastrodia elata Bl. and their anti-dengue virus bioactivities[J]. CARBOHYDRATE RESEARCH,2007,342(15):2230-2236. |
| APA | Qiu, Hong,Tang, Wei,Tong, Xiankun,Ding, Kan,&Zuo, Jianping.(2007).Structure elucidation and sulfated derivatives preparation of two alpha-D-glucans from Gastrodia elata Bl. and their anti-dengue virus bioactivities.CARBOHYDRATE RESEARCH,342(15),2230-2236. |
| MLA | Qiu, Hong,et al."Structure elucidation and sulfated derivatives preparation of two alpha-D-glucans from Gastrodia elata Bl. and their anti-dengue virus bioactivities".CARBOHYDRATE RESEARCH 342.15(2007):2230-2236. |
入库方式： OAI收割
来源：上海药物研究所
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