Magnesium tanshinoate B protects endothelial cells against oxidized lipoprotein-induced apoptosis
文献类型：期刊论文
| 作者 | Au-Yeung, Kathy K. W.; Karmin, O.4; Choy, Patrick C.; Zhu, Da-yuan5; Siow, Yaw L.1,2,3 |
| 刊名 | CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
 |
| 出版日期 | 2007-11 |
| 卷号 | 85期号:11页码:1053-1062 |
| 关键词 | danshen antioxidant oxidized lipoproteins JNK signaling pathway apoptosis |
| ISSN号 | 0008-4212 |
| DOI | 10.1139/Y07-096 |
| 文献子类 | Article |
| 英文摘要 | The activation of c-Jun N-terminal kinase (JNK) signaling pathway plays an important role in the induction of cell apoptosis. We previously reported that magnesium tanshinoate B (MTB), a compound purified from a Chinese herb danshen (Salvia miltiorrhiza), could inhibit ischemia/reperfusion-induced myocyte apoptosis in the heart. The objective of the present study was to investigate whether MTB can prevent oxidized lipoprotein-induced apoptosis in endothelial cells. Human umbilical vein endothelial cells (HUVECs) were incubated with copper-oxidized very low density lipoprotein (Cu-OxVLDL) or copper-oxidized low density lipoprotein (Cu-OxLDL). Treatment of cells with Cu-OxVLDL or Cu-OxLDL resulted in a 3-fold increase in the JNK activity. The amount of cytochrome c released and the activity of caspase-3 in cells treated with Cu-OxVLDL or Cu-OxLDL were significantly elevated, indicating the occurrence of apoptosis. The presence of MTB was able to abolish the JNK activation, cytochrome c release, and caspase-3 activation induced by Cu-OxVLDL or Cu-OxLDL, resulting in a marked reduction in apoptosis in endothelial cells. The data from this study indicate that oxidized lipoproteins induce apoptosis in endothelial cells. We postulate that the inhibition of the JNK signaling pathway by MTB is a key mechanism that protects these cells from oxidized lipoprotein-induced apoptosis. |
| WOS关键词 | SALVIAE-MILTIORRHIZAE-RADIX ; LITHOSPERMIC ACID-B ; C-JUN ; NITRIC-OXIDE ; CYTOCHROME-C ; CARDIOVASCULAR-DISEASE ; SIGNALING PATHWAYS ; MAP KINASES ; OX-LDL ; ACTIVATION |
| WOS研究方向 | Pharmacology & Pharmacy ; Physiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000252309800001 |
| 出版者 | NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273119]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Siow, Yaw L. |
| 作者单位 | 1.Univ Manitoba, Dept Physiol, St Boniface Hosp Res Ctr,Innovative Therapy Res L, Fac Med,Canadian Ctr Agrifood Res Hlth & Med, Winnipeg, MB R2H 2A6, Canada; 2.Univ Manitoba, Dept Biochem & Med Genet, St Boniface Hosp Res Ctr,Innovative Therapy Res L, Fac Med,Canadian Ctr Agrifood Res Hlth & Med, Winnipeg, MB R2H 2A6, Canada; 3.Univ Manitoba, Ctr Res & Treatment Atherosclerosis, St Boniface Hosp Res Ctr, Innovat Therapy Res Lab, Winnipeg, MB R2H 2A6, Canada; 4.Univ Manitoba, Dept Anim Sci, Winnipeg, MB R2H 2A6, Canada; 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Au-Yeung, Kathy K. W.,Karmin, O.,Choy, Patrick C.,et al. Magnesium tanshinoate B protects endothelial cells against oxidized lipoprotein-induced apoptosis[J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY,2007,85(11):1053-1062. |
| APA | Au-Yeung, Kathy K. W.,Karmin, O.,Choy, Patrick C.,Zhu, Da-yuan,&Siow, Yaw L..(2007).Magnesium tanshinoate B protects endothelial cells against oxidized lipoprotein-induced apoptosis.CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY,85(11),1053-1062. |
| MLA | Au-Yeung, Kathy K. W.,et al."Magnesium tanshinoate B protects endothelial cells against oxidized lipoprotein-induced apoptosis".CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 85.11(2007):1053-1062. |
入库方式： OAI收割
来源：上海药物研究所
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