Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation
文献类型：期刊论文
| 作者 | Meng, Ling-Hua ; Ding, Jian
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2007-09 |
| 卷号 | 28期号:9页码:1460-1465 |
| 关键词 | salvicine topoisomerase II ROS DNA damage multidrug-resisitant antimetastasis |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2007.00698.x |
| 文献子类 | Review |
| 英文摘要 | Salvicine is a novel diterpenoid quinone compound obtained by structural modification of a natural product lead isolated from a Chinese herb with potent growth inhibitory activity against a wide spectrum of human tumor cells in vitro and in mice bearing human tumor xenografts. Salvicine has also been found to have a profound cytotoxic effect on multidrug-resisitant (MDR) cells. Moreover, Salvicine significantly reduced the lung metastatic foci of MDA-MB-435 orthotopic xenograft. Recent studies demonstrated that salvicine is a novel non-intercalative topoisomerase II (Topo II) poison by binding to the ATPase domain, promoting DNA-Topo II binding and inhibiting Topo II-mediated DNA relegation and ATP hydrolysis. Further studies have indicated that salcivine-elicited ROS plays a central role in salvicine-induced cellular response including Topo II inhibition, DNA damage, circumventing MDR and tumor cell adhesion inhibition. |
| WOS关键词 | MEDIATED DNA-DAMAGE ; DEPENDENT PATHWAY ; DOWN-REGULATION ; EARLY EVENT ; APOPTOSIS ; ACTIVATION ; CELLS ; INDUCTION ; CYTOTOXICITY ; SPECTROSCOPY |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3089078 |
| WOS记录号 | WOS:000249220900019 |
| 出版者 | BLACKWELL PUBLISHING |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273151]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ding, Jian |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Meng, Ling-Hua,Ding, Jian. Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation[J]. ACTA PHARMACOLOGICA SINICA,2007,28(9):1460-1465. |
| APA | Meng, Ling-Hua,&Ding, Jian.(2007).Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation.ACTA PHARMACOLOGICA SINICA,28(9),1460-1465. |
| MLA | Meng, Ling-Hua,et al."Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation".ACTA PHARMACOLOGICA SINICA 28.9(2007):1460-1465. |
入库方式： OAI收割
来源：上海药物研究所
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