Huperzine a from Huperzia species - an ethnopharmacolgical review
文献类型：期刊论文
| 作者 | Ma, Xiaoqiang; Tan, Changheng ; Zhu, Dayuan; Gang, David R.; Xiao, Peigen
|
| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 出版日期 | 2007-08-15 |
| 卷号 | 113期号:1页码:15-34 |
| 关键词 | huperzine A ZT-1 Alzheimer's disease Huperzia serrata huperziaceae drug discovery bioactivities clinical trials traditional chinese medicine |
| ISSN号 | 0378-8741 |
| DOI | 10.1016/j.jep.2007.05.030 |
| 文献子类 | Review |
| 英文摘要 | Huperzine A (HupA), isolated originally from a traditional Chinese medicine Qiang Ceng Ta, whole plant of Huperzia serrata (Thunb. ex Murray) Trev., a member of the Huperziaceae family, has attracted intense attention since its marked anticholinesterase activity was discovered by Chinese scientists. Several members of the Huperziaceae (Huperzia and Phlegmariurus species) have been used as medicines in China for contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate poisoning. HupA has been marketed in China as a new drug for Alzheimer's disease (AD) treatment and its derivative ZT-1 is being developed as anti-AD new drug candidate both in China and in Europe. A review of the chemistry, bioactivities, toxicology, clinical trials and natural resources of HupA source plants is presented. (c) 2007 Elsevier Ireland Ltd. Ail rights reserved. |
| WOS关键词 | LYCOPODIUM-SERRATUM THUNB ; NATURAL CHOLINESTERASE INHIBITOR ; INDUCED OXIDATIVE INJURY ; CHINESE HERBAL MEDICINE ; SOMAN-INDUCED SEIZURES ; ALZHEIMERS-DISEASE ; ANTICHOLINESTERASE ACTIVITY ; ACETYLCHOLINESTERASE INHIBITOR ; A-C ; DISCRIMINATION PERFORMANCE |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000249055200002 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273177]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Xiao, Peigen |
| 作者单位 | 1.Univ Arizona, Dept Plant Sci, Tucson, AZ 85721 USA 2.Peking Union Med Coll, Inst Med Plant Dev, Beijing 100094, Peoples R China 3.Chinese Acad Sci, Beijing 100094, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Univ Arizona, BIO5 Inst, Tucson, AZ 85721 USA |
| 推荐引用方式 GB/T 7714 | Ma, Xiaoqiang,Tan, Changheng,Zhu, Dayuan,et al. Huperzine a from Huperzia species - an ethnopharmacolgical review[J]. JOURNAL OF ETHNOPHARMACOLOGY,2007,113(1):15-34. |
| APA | Ma, Xiaoqiang,Tan, Changheng,Zhu, Dayuan,Gang, David R.,&Xiao, Peigen.(2007).Huperzine a from Huperzia species - an ethnopharmacolgical review.JOURNAL OF ETHNOPHARMACOLOGY,113(1),15-34. |
| MLA | Ma, Xiaoqiang,et al."Huperzine a from Huperzia species - an ethnopharmacolgical review".JOURNAL OF ETHNOPHARMACOLOGY 113.1(2007):15-34. |
入库方式： OAI收割
来源：上海药物研究所
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