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Two new biscembranes with unprecedented carbon skeleton and their probable biogenetic precursor from the Hainan soft coral Sarcophyton latum

文献类型：期刊论文

作者Yan, Xiao-Hong; Gavagnin, Margherita; Cimino, Guido; Guo, Yue-Wei
刊名TETRAHEDRON LETTERS
出版日期2007-07-23
卷号48期号:30页码:5313-5316
关键词soft coral Sarcophyton latum biscembranes
ISSN号0040-4039
DOI10.1016/j.tetlet.2007.05.096
文献子类Article
英文摘要A new cembranolide diterpene, isosarcophytonolide D (1), and two biscembranes with an unprecedented fused carbon skeleton, bislatumlides A (3) and B (4), were isolated from the Hainan soft coral Sarcophyton latum. Their structures and relative stereochemistry were established by I D and 2D NMR spectroscopic techniques. Compounds 3 and 4 should be obtained by Diels-Alder addition of two cembranoid units. Compound I could be one of the biosynthetic precursors. Both 3 and 4 showed mild cytotoxicity toward A549, HT-29, and P388 cell lines. (C) 2007 Elsevier Ltd. All rights reserved.
WOS关键词METHYL SARTORTUOATE ; GLAUCUM ; CEMBRANOLIDES ; TORTUOSUM ; UNIQUE
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000248155000033
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/273198]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Guo, Yue-Wei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.CNR, Ist Chim Biomol, I-80078 Pozzuoli, Naples, Italy
推荐引用方式
GB/T 7714		 Yan, Xiao-Hong,Gavagnin, Margherita,Cimino, Guido,et al. Two new biscembranes with unprecedented carbon skeleton and their probable biogenetic precursor from the Hainan soft coral Sarcophyton latum[J]. TETRAHEDRON LETTERS,2007,48(30):5313-5316.
APA Yan, Xiao-Hong,Gavagnin, Margherita,Cimino, Guido,&Guo, Yue-Wei.(2007).Two new biscembranes with unprecedented carbon skeleton and their probable biogenetic precursor from the Hainan soft coral Sarcophyton latum.TETRAHEDRON LETTERS,48(30),5313-5316.
MLA Yan, Xiao-Hong,et al."Two new biscembranes with unprecedented carbon skeleton and their probable biogenetic precursor from the Hainan soft coral Sarcophyton latum".TETRAHEDRON LETTERS 48.30(2007):5313-5316.

入库方式： OAI收割

来源：上海药物研究所

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