3-Arylamino-2H-1,2,4-benzothiadiazin-5-oI 1,1-dioxides as novel and selective CXCR2 antagonists
文献类型：期刊论文
| 作者 | Wang, Yonghui; Busch-Petersen, Jakob; Wang, Feng; Ma, Lanping ; Fu, Wei; Kerns, Jeffrey K.; Jin, Jian; Palovich, Michael R.; Shen, Jing-Kang; Burman, Miriam
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2007-07-15 |
| 卷号 | 17期号:14页码:3864-3867 |
| 关键词 | CXCR2 antagonists interleukin-8 chemokines cyclic sulfonamides inflammation |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2007.05.011 |
| 文献子类 | Article |
| 英文摘要 | A series of 3-arylamino-2H-1,2,4-benzothiadiazin-5-oI 1,1-dioxides were prepared and shown to be novel and selective antagonists of the CXCR2 receptor. Synthesis, structure and activity relationships, selectivity, and some developability properties are described. (C) 2007 Elsevier Ltd. All rights reserved. |
| WOS关键词 | HUMAN INTERLEUKIN-8 RECEPTOR ; SMALL-MOLECULE ANTAGONISTS ; CHEMOKINE RECEPTOR ; NEUTROPHIL ; POTENT ; IDENTIFICATION ; EXPRESSION ; CLONING |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000248074600011 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273201]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Wang, Yonghui |
| 作者单位 | 1.GlaxoSmithKline Inc, Discovery Med Chem, Collegeville, PA 19426 USA 2.GlaxoSmithKline Inc, Resp & Immflamat CEDD, King Of Prussia, PA 19406 USA 3.Chinese Acad Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai 20103, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yonghui,Busch-Petersen, Jakob,Wang, Feng,et al. 3-Arylamino-2H-1,2,4-benzothiadiazin-5-oI 1,1-dioxides as novel and selective CXCR2 antagonists[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(14):3864-3867. |
| APA | Wang, Yonghui.,Busch-Petersen, Jakob.,Wang, Feng.,Ma, Lanping.,Fu, Wei.,...&Widdowson, Katherine L..(2007).3-Arylamino-2H-1,2,4-benzothiadiazin-5-oI 1,1-dioxides as novel and selective CXCR2 antagonists.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,17(14),3864-3867. |
| MLA | Wang, Yonghui,et al."3-Arylamino-2H-1,2,4-benzothiadiazin-5-oI 1,1-dioxides as novel and selective CXCR2 antagonists".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17.14(2007):3864-3867. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。