Design, synthesis and in vitro evaluation of L-amino acid esters prodrugs of acyclic nucleoside phosphonates as anti-HBV agent
文献类型：期刊论文
| 作者 | Fu, Xiao Zhong; Jiang, Sai Hong; Xin, Jian; Yang, Yu She; Ji, Ru Yun |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2007-07 |
| 卷号 | 18期号:7页码:817-819 |
| 关键词 | acyclic nucleoside phosphonates L-amino acid prodrug anti-HBV activity |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2007.05.013 |
| 文献子类 | Article |
| 英文摘要 | Aseries of novel L-amino acid esters prodrugs of acyclic nucleoside phosphonates was synthesized and their anti-HBV activity was evaluated in HepG2 2.2.15 cells. Compound 1d exhibited more potent anti-HBV activity and lower cytotoxicity than those of adefovir dipivoxil with EC50 and CC50 values of 0.207 mu mol/L and 2530 mu mol/L, respectively. (C) 2007 Yu She Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000248207000015 |
| 出版者 | CHINESE CHEMICAL SOCIETY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273210]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Yu She |
| 作者单位 | 1.Coll Med, Sch Pharm, Guiyang 550004, Peoples R China 2.Chinese Acad Sci, Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Shanghai Fudan Yueda Bio Tech Co Ltd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Xiao Zhong,Jiang, Sai Hong,Xin, Jian,et al. Design, synthesis and in vitro evaluation of L-amino acid esters prodrugs of acyclic nucleoside phosphonates as anti-HBV agent[J]. CHINESE CHEMICAL LETTERS,2007,18(7):817-819. |
| APA | Fu, Xiao Zhong,Jiang, Sai Hong,Xin, Jian,Yang, Yu She,&Ji, Ru Yun.(2007).Design, synthesis and in vitro evaluation of L-amino acid esters prodrugs of acyclic nucleoside phosphonates as anti-HBV agent.CHINESE CHEMICAL LETTERS,18(7),817-819. |
| MLA | Fu, Xiao Zhong,et al."Design, synthesis and in vitro evaluation of L-amino acid esters prodrugs of acyclic nucleoside phosphonates as anti-HBV agent".CHINESE CHEMICAL LETTERS 18.7(2007):817-819. |
入库方式： OAI收割
来源：上海药物研究所
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