Suppressive effect of a novel water-soluble artemisinin derivative SM905 on T cell activation and proliferation in vitro and in vivo
文献类型：期刊论文
| 作者 | Wang, Jun-Xia; Tang, Wei ; Yang, Zhong-Shun; Wan, Jin; Shi, Li-Ping; Zhang, Yu; Zhou, Ru; Ni, Jia; Hou, Li-Fei; Zhou, Yu
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| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2007-06-14 |
| 卷号 | 564期号:1-3页码:211-218 |
| ISSN号 | 0014-2999 |
| 关键词 | SM905 artemisinin derivative immunosuppression T cell activation and proliferation MAP kinase Ras |
| DOI | 10.1016/j.ejphar.2007.01.092 |
| 文献子类 | Article |
| 英文摘要 | Artemisinin and its derivatives exhibit potent immunosuppressive activity. The aim of this study was to investigate the suppressive effects of SM905, a new water-soluble artemisinin derivative, on T lymphocytes both in vitro and in vivo, and explore its potential mode of action. The results showed that SM905 had a high inhibitory activity in Concanavalin A (ConA)-induced splenocyte proliferation and mixed lymphocyte reaction, and a relatively low cytotoxicity in vitro. In ovalbumin-immunized mice, oral administration of SM905 dose-dependently suppressed T cell proliferative response to ovalbumin, and inhibited anti-ovalbumin interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) production by T cells. Further studies showed that SM905 inhibited TCR (T cell receptor)/CD3 plus CD28-mediated primary T cell proliferation and cytokine production (IL-2 and IFN-gamma), and exerted an inhibitory action on the phosphorylation of mitogen-activated protein (MAP) kinases including extracellular signal-regulated kinase (ERK), p38 and Jun N-terminal kinase (JNK), and the activation of Ras. The results of this study provided experimental evidence that the new artemisinin derivative SM905 had immunosuppressive effects both in vitro and in vivo. SM905 suppressed T cell activation, which was associated with the inhibition of MAP kinases and Ras activation. Our results suggested a potential of SM905 to be developed as a new type agent for treating T cell-mediated immune disorder. (c) 2007 Elsevier B.V. All rights reserved. |
| WOS关键词 | EXPERIMENTAL RHEUMATOID-ARTHRITIS ; COLLAGEN-INDUCED ARTHRITIS ; IMMUNOSUPPRESSIVE ACTIVITY ; SIGNAL-TRANSDUCTION ; AUTOIMMUNE ; COSTIMULATION ; LYMPHOCYTES ; INTEGRATION ; ARTESUNATE ; CYTOKINES |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000246998800028 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273225]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第一研究室 |
| 通讯作者 | Li, Ying |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Synthet Chem, State Key Lab Drug Res,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol 1, State Key Lab Drug Res,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jun-Xia,Tang, Wei,Yang, Zhong-Shun,et al. Suppressive effect of a novel water-soluble artemisinin derivative SM905 on T cell activation and proliferation in vitro and in vivo[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2007,564(1-3):211-218. |
| APA | Wang, Jun-Xia.,Tang, Wei.,Yang, Zhong-Shun.,Wan, Jin.,Shi, Li-Ping.,...&Zuo, Jian-Ping.(2007).Suppressive effect of a novel water-soluble artemisinin derivative SM905 on T cell activation and proliferation in vitro and in vivo.EUROPEAN JOURNAL OF PHARMACOLOGY,564(1-3),211-218. |
| MLA | Wang, Jun-Xia,et al."Suppressive effect of a novel water-soluble artemisinin derivative SM905 on T cell activation and proliferation in vitro and in vivo".EUROPEAN JOURNAL OF PHARMACOLOGY 564.1-3(2007):211-218. |
入库方式： OAI收割
来源：上海药物研究所
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