Behavioral recovery following sub-chronic paeoniflorin administration in the striatal 6-OHDA lesion rodent model of Parkinson's disease
文献类型：期刊论文
| 作者 | Liu, Da-Zhi; Zhu, Jun; Jin, Dao-Zhong; Zhang, Li-Min; Ji, Xin-Quan; Ye, Yang ; Tang, Chun-Ping; Zhu, Xing-Zu
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| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
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| 出版日期 | 2007-06-13 |
| 卷号 | 112期号:2页码:327-332 |
| 关键词 | paeoniflorin Paeoniae radix behavior recovery adenosine A(1) receptor striatal 6-hydroxydopamine-lesion rat non-dopaminergic approach Parkinson's disease |
| ISSN号 | 0378-8741 |
| DOI | 10.1016/j.jep.2007.03.022 |
| 文献子类 | Article |
| 英文摘要 | In the present studies, the effect of paeoniflorin (PF), one of the main compounds extracted from Paeoniae radix, in alleviating the neurological impairment following unilateral striatal 6-hydroxydopamine (6-OHDA) lesion was examined in Sprague-Dawley rats. Sub-chronic PF (2.5, 5 and 10mg/kg, s.c., twice daily for 11 days) administration dose-dependently reduced apornorphine (APO)-induced rotation, suggesting that PF had an ameliorative effect on the 6-OHDA-induced neurological impairment. Notably, PF had no direct action on dopamine D-1 receptor or dopamine D-2 receptor indicated by the competitive binding experiments. These results suggest that PF, an active component of Paeoniae radix, might provide an opportunity to introduce a non-dopaminergic management of Parkinson's disease. (c) 2007 Elsevier Ireland Ltd. All rights reserved. |
| WOS关键词 | ADENOSINE A(1) RECEPTORS ; CENTRAL-NERVOUS-SYSTEM ; ROTATIONAL BEHAVIOR ; WHITE ADIPOCYTES ; RAT ; ACTIVATION ; INCREASE ; NEURONS ; PROTEIN ; N-6-CYCLOPENTYLADENOSINE |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000247359500017 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273226]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhu, Xing-Zu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol 2, Shanghai 201203, Peoples R China 2.Fudan Univ, Shanghai Med Coll, Dept Neurol, Huashan Hosp, Shanghai 200040, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Da-Zhi,Zhu, Jun,Jin, Dao-Zhong,et al. Behavioral recovery following sub-chronic paeoniflorin administration in the striatal 6-OHDA lesion rodent model of Parkinson's disease[J]. JOURNAL OF ETHNOPHARMACOLOGY,2007,112(2):327-332. |
| APA | Liu, Da-Zhi.,Zhu, Jun.,Jin, Dao-Zhong.,Zhang, Li-Min.,Ji, Xin-Quan.,...&Zhu, Xing-Zu.(2007).Behavioral recovery following sub-chronic paeoniflorin administration in the striatal 6-OHDA lesion rodent model of Parkinson's disease.JOURNAL OF ETHNOPHARMACOLOGY,112(2),327-332. |
| MLA | Liu, Da-Zhi,et al."Behavioral recovery following sub-chronic paeoniflorin administration in the striatal 6-OHDA lesion rodent model of Parkinson's disease".JOURNAL OF ETHNOPHARMACOLOGY 112.2(2007):327-332. |
入库方式： OAI收割
来源：上海药物研究所
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