Simultaneous stereoselective 4-amination with cyclic secondary amines and 2-O-deacetylation of peracetylated sialic acid derivatives
文献类型：期刊论文
| 作者 | Ye, Deju; Li, Jian; Zhang, Jian; Liu, Hong ; Jiang, Hualiang
|
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2007-06-04 |
| 卷号 | 48期号:23页码:4023-4027 |
| 关键词 | sialic acid derivatives cyclic secondary amines deacetylation Neu5Ac neuraminidase inhibitors H5N1 |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2007.04.023 |
| 文献子类 | Article |
| 英文摘要 | Treatment of methyl 5-acetamido-2,4,7,8,9-penta-O-acetyl-3,5-dideoxy-beta-L-glycero-D-galacto-2-nonulopyranosidonate (1) with cyclic secondary amines in pyridine at room temperature for 24 h afforded unusual products (2a-g). Related experiments were carried out to explain the formation of 4-amination and 2-O-deacetylation of peracetylated sialic acid derivatives (2a-g). This reaction may provide a new strategy for the preparation of Zanamivir analogues as neuraminidase inhibitors for anti-H5N1 subtype of avian influenza virus (AIV). (c) 2007 Elsevier Ltd. All rights reserved. |
| WOS关键词 | N-ACETYLNEURAMINIC ACID ; CARBOHYDRATE-CHEMISTRY ; STRUCTURAL VARIATIONS ; EFFICIENT SYNTHESIS ; 8-O-SIALYLATION ; BEHAVIOR ; ANALOGS ; VIRUS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000246796000019 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273230]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res,Ctr Drug Discovery & Desig, Shanghai 201203, Peoples R China 2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Deju,Li, Jian,Zhang, Jian,et al. Simultaneous stereoselective 4-amination with cyclic secondary amines and 2-O-deacetylation of peracetylated sialic acid derivatives[J]. TETRAHEDRON LETTERS,2007,48(23):4023-4027. |
| APA | Ye, Deju,Li, Jian,Zhang, Jian,Liu, Hong,&Jiang, Hualiang.(2007).Simultaneous stereoselective 4-amination with cyclic secondary amines and 2-O-deacetylation of peracetylated sialic acid derivatives.TETRAHEDRON LETTERS,48(23),4023-4027. |
| MLA | Ye, Deju,et al."Simultaneous stereoselective 4-amination with cyclic secondary amines and 2-O-deacetylation of peracetylated sialic acid derivatives".TETRAHEDRON LETTERS 48.23(2007):4023-4027. |
入库方式： OAI收割
来源：上海药物研究所
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