Depside salts from Salvia miltiorrhiza improve myocardial microperfusion in rats using laser Doppler flowmetry
文献类型：期刊论文
| 作者 | Li, Xiao-fen; Wang, Yi-ping
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2007-06 |
| 卷号 | 28期号:6页码:789-795 |
| 关键词 | lithospermate B myocardial microperfusion laser Doppler flowmetry cardiac output ultrasonic Doppler flowmetry |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2007.00546.x |
| 文献子类 | Article |
| 英文摘要 | Aim: To investigate the effects of depside salts from Salvia miltiorrhiza on myocardial microperfusion and systemic hemodynamics in open-chest anaesthetized Sprague-Dawley rats. Methods: Myocardial microperfusion was measured by laser Doppler flowmetry with a needle probe; cardiac output (CO) was determined using ultrasonic Doppler flowmetry. Other hemodynamic parameters, including femoral artery blood pressure, cardiac inotropy, and systemic vascular resistance (SVR) were simultaneously recorded by the PowerLab system. Results: Intravenous administration of S miltiorrhiza depside salts resulted in a significant immediate increase in CO and cardiac inotropy, but a fall in SVR. S miltiorrhiza depside salts (30 mg/kg and 60 mg/kg) promoted cardiac index (CI) by 12.2%+/- 6.3% (P < 0.01 vs baseline) and 20.1%+/- 3.5% (P < 0.01), respectively. Myocardial microperfusion maxi mally i n cr eased by 6.3%+/- 2.9% (P < 0.01) an d 9.6%+/- 4.0% (P < 0.01) for 30 mg/kg and 60 mg/kg S miltiorrhiza depside salts, respectively. Conclusion: These results indicated that S miltiorrhiza depside salts improved myocardial micro-perfusion, as well as CO. |
| WOS关键词 | MAGNESIUM LITHOSPERMATE-B ; ACID-B ; VENTRICULAR MYOCYTES ; ENDOTHELIAL-CELLS ; NITRIC-OXIDE ; BLOOD-FLOW ; CALCIUM ; HEART ; PERFUSION ; INHIBITION |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:2845670 |
| WOS记录号 | WOS:000246756300006 |
| 出版者 | BLACKWELL PUBLISHING |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273234]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Yi-ping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiao-fen,Wang, Yi-ping. Depside salts from Salvia miltiorrhiza improve myocardial microperfusion in rats using laser Doppler flowmetry[J]. ACTA PHARMACOLOGICA SINICA,2007,28(6):789-795. |
| APA | Li, Xiao-fen,&Wang, Yi-ping.(2007).Depside salts from Salvia miltiorrhiza improve myocardial microperfusion in rats using laser Doppler flowmetry.ACTA PHARMACOLOGICA SINICA,28(6),789-795. |
| MLA | Li, Xiao-fen,et al."Depside salts from Salvia miltiorrhiza improve myocardial microperfusion in rats using laser Doppler flowmetry".ACTA PHARMACOLOGICA SINICA 28.6(2007):789-795. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。