Myeloid suppressor cell-associated immune dysfunction in CSA1M fibrosarcoma tumor-bearing mice
文献类型：期刊论文
| 作者 | Zhou, Ru; He, Pei-Lan; Ren, Yong-Xin; Wang, Wen-Hai; Zhou, Rong-Yao; Wan, Hua; Ono, Shiro; Fujiwara, Hiromi; Zuo, Jian-Ping
|
| 刊名 | CANCER SCIENCE
 |
| 出版日期 | 2007-06 |
| 卷号 | 98期号:6页码:882-889 |
| ISSN号 | 1347-9032 |
| DOI | 10.1111/j.1349-7006.2007.00465.x |
| 文献子类 | Article |
| 英文摘要 | CSA1M tumor-bearing mice exhibited a severe immune dysfunction but the underlying mechanism remained unclear. In this study, we demonstrated that the myeloid suppressor cell (Mac-1(+)Gr-1(+) cells)-(MSC) related T cell immunosuppression in this tumor-bearing model. In mice at the late stage of CSA1M tumor-bearing (Late TB [8-10 weeks after cell inoculation in male BALB/c mice]), the percentages for CD4(+) and CD8(+) T cells decreased but Mac-1(+) cells increased in spleens with severe splenomegaly. There was no deficit for concanavalin A-induced CD4(+) and CD8(+) T cell proliferation, interferon-gamma (IFN-gamma) and interleukin (IL)-4 production, but delayed-type hypersensitivity reaction were attenuated. Analysis of cytokine production in unfractionated spleen cells showed a significant reduction of IFN-gamma and a marked increase of IL-10 and IL-4. In Late-TB mice, splenic MSC number intensively accumulated; the mRNA expressions of the signal transducer and activator of transcription 1, interferon regulatory factor 1 (IRF-1), and inducible nitric-oxide synthase (iNOS) were enhanced in MSC; the nitric oxide production and arginase enzyme activity increased in MSC as well. Furthermore, the concanavalin A-induced T cell proliferation was inhibited in the presence of lipopolysaccharide- or IFN-gamma-activated MSC from Late-TB mice, which could be reversed by the iNOS specific inhibitor L-NMMA. iNOS seemed to be required more than arginase for the suppressive activity of MSC. Taken together, our results suggest that the immune dysfunction in tumor-bearing mice might be causally associated with the accumulation of MSC and its tumor-favoring property. |
| WOS关键词 | MACROPHAGE ARGININE METABOLISM ; NITRIC-OXIDE ; INTERFERON-GAMMA ; T-CELLS ; CANCER ; INHIBITION ; EXPRESSION ; RESPONSES ; (5R)-5-HYDROXYTRIPTOLIDE ; INTERLEUKIN-10 |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000246028300017 |
| 出版者 | BLACKWELL PUBLISHING |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273237]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zuo, Jian-Ping |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai 201203, Peoples R China 2.Osaka Univ, Grad Sch Med, Dept Oncol, Suita, Osaka 5650871, Japan 3.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Lab Immunopharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Ru,He, Pei-Lan,Ren, Yong-Xin,et al. Myeloid suppressor cell-associated immune dysfunction in CSA1M fibrosarcoma tumor-bearing mice[J]. CANCER SCIENCE,2007,98(6):882-889. |
| APA | Zhou, Ru.,He, Pei-Lan.,Ren, Yong-Xin.,Wang, Wen-Hai.,Zhou, Rong-Yao.,...&Zuo, Jian-Ping.(2007).Myeloid suppressor cell-associated immune dysfunction in CSA1M fibrosarcoma tumor-bearing mice.CANCER SCIENCE,98(6),882-889. |
| MLA | Zhou, Ru,et al."Myeloid suppressor cell-associated immune dysfunction in CSA1M fibrosarcoma tumor-bearing mice".CANCER SCIENCE 98.6(2007):882-889. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。