Involvement of MI-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha
文献类型：期刊论文
| 作者 | Yan, Han; Zhang, Hai Yan; Tang, Xi Can |
| 刊名 | NEUROREPORT
 |
| 出版日期 | 2007-05-07 |
| 卷号 | 18期号:7页码:689-692 |
| 关键词 | amyloid precursor protein huperzine A MI-muscarinic acetylcholine receptor mitogen-activated protein kinase protein kinase C |
| ISSN号 | 0959-4965 |
| DOI | 10.1097/WNR.0b013e3280c1e28c |
| 文献子类 | Article |
| 英文摘要 | This study is to explore the involvement of muscarinic acetylcholine receptors/protein kinase C cascade and the mitogen-activated protein kinase pathway in the effect of huperzine A on the secretory amyloid precursor protein-alpha. Upregulation of secretory amyloid precursor protein-a by huperzine A was attenuated by muscarinic acetylcholine receptor antagonist (specifically by MI-muscarinic acetylcholine receptor antagonist), and markedly blocked (-377%) by protein kinase C inhibitor as well. Meanwhile, huperzine A can activate the phosphorylation of mitogen-activated protein kinase and, accordingly, partly restored PD98059-decreased secretory amyloid precursor protein-alpha secretion. In addition, huperzine A largely inhibited (-55.4%) acetylcholinesterase activity of the cell line. Our results suggest that activated MI-muscarinic acetylcholine receptor/protein kinase C pathway and mitogen-activated protein kinase signaling are involved in the process of huperzine A enhancing the secretory amyloid precursor protein-alpha secretion. |
| WOS关键词 | ALZHEIMERS-DISEASE ; IN-VITRO ; LEVEL ; AGONISTS ; CELLS |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000245856000014 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273260]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Tang, Xi Can |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Han,Zhang, Hai Yan,Tang, Xi Can. Involvement of MI-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha[J]. NEUROREPORT,2007,18(7):689-692. |
| APA | Yan, Han,Zhang, Hai Yan,&Tang, Xi Can.(2007).Involvement of MI-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha.NEUROREPORT,18(7),689-692. |
| MLA | Yan, Han,et al."Involvement of MI-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha".NEUROREPORT 18.7(2007):689-692. |
入库方式： OAI收割
来源：上海药物研究所
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