l-Stepholidine increases the frequency of sEPSC via the activation of D-1 dopamine signaling pathway in rat prelimbic cortical neurons
文献类型：期刊论文
| 作者 | Gao, Ming; Liu, Chang-liang; Yang, Shen; Zhen, Xue-chu; Jin, Guo-zhang
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2007-05 |
| 卷号 | 28期号:5页码:627-633 |
| 关键词 | l-stepholidine prelimbic cortex whole-cell patch clamp spontaneous excitatory postsynaptic currents dopamine receptor |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2007.00547.x |
| 文献子类 | Article |
| 英文摘要 | Aim: To investigate the effect of l-stepholidine (SPD) on the frequency of spontaneous excitatory postsynaptic currents (sEPSC) in the pyramidal cells between layers V and VI in the prelimbic cortex (PL). Methods: A whole-cell patch clamp in rat brain slices was used. Results: SPD significantly increased the frequency of sEPSC in a concentration-dependent manner. A selective D-1 dopamine receptor antagonist SCH23390 blocked SPD-mediated effects, whereas the D-1 agonist SKF38393, but not the D-2/3 antagonist sulpiride, mimicked SPD-mediated increase in the frequency of sEPSC. Moreover, both protein kinase A (PKA) inhibitor N-(2-[p-bromocinnamylamino]-ethyl)-5-isoquinolinesulfonamide hydrochloride and protein kinase C (PKC) inhibitor chelerythrine attenuated the effect of SPD on sEPSC. Conclusion: SPD elicits its effect on the frequency of sEPSC on the PL pyramidal cells via presynaptic D-1 receptors, and is dependent on PKA and PKC signaling pathways. |
| WOS关键词 | EXCITATORY POSTSYNAPTIC CURRENTS ; PREFRONTAL CORTEX ; ANTIPSYCHOTIC-DRUGS ; ADENYLATE-CYCLASE ; RECEPTOR AGONIST ; PYRAMIDAL CELLS ; FIRING ACTIVITY ; WORKING-MEMORY ; SCHIZOPHRENIA ; (-)-STEPHOLIDINE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000246150800004 |
| 出版者 | BLACKWELL PUBLISHING |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273262]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Jin, Guo-zhang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res,Dept Pharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Ming,Liu, Chang-liang,Yang, Shen,et al. l-Stepholidine increases the frequency of sEPSC via the activation of D-1 dopamine signaling pathway in rat prelimbic cortical neurons[J]. ACTA PHARMACOLOGICA SINICA,2007,28(5):627-633. |
| APA | Gao, Ming,Liu, Chang-liang,Yang, Shen,Zhen, Xue-chu,&Jin, Guo-zhang.(2007).l-Stepholidine increases the frequency of sEPSC via the activation of D-1 dopamine signaling pathway in rat prelimbic cortical neurons.ACTA PHARMACOLOGICA SINICA,28(5),627-633. |
| MLA | Gao, Ming,et al."l-Stepholidine increases the frequency of sEPSC via the activation of D-1 dopamine signaling pathway in rat prelimbic cortical neurons".ACTA PHARMACOLOGICA SINICA 28.5(2007):627-633. |
入库方式： OAI收割
来源：上海药物研究所
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