Baicalin protects mouse from Concanavalin A-induced liver injury through inhibition of cytokine production and hepatocyte apoptosis
文献类型：期刊论文
| 作者 | Liu, Lin-lin; Gong, Li-kun ; Wang, Hui; Xiao, Ying; Wu, Xiong-fei; Zhang, Yun-hai; Xue, Xiang; Qi, Xin-ming; Ren, Jin
|
| 刊名 | LIVER INTERNATIONAL
 |
| 出版日期 | 2007-05 |
| 卷号 | 27期号:4页码:582-591 |
| 关键词 | apoptosis baicalin cytokine Concanavalin A-induced hepatitis |
| ISSN号 | 1478-3223 |
| DOI | 10.1111/j.1478-3231.2007.01450.x |
| 文献子类 | Article |
| 英文摘要 | Background: Baicalin (BA) exhibits an anti-inflammatory effect in vivo and in vitro and is used to treat chronic hepatitis. However, the mechanism by which BA exerts the liver-protective effect remains largely unknown. Aims: The present study reports that BA inhibits cytokine production and hepatocyte apoptosis to protect mice from liver injury induced by concanavalin A (Con A), a T-cell-dependent liver injury model. Results: Con A injection of mice induced severe immune responses and extensive hepatocellular apoptosis within 24 h. Pretreatment of 200 or 100 mg/kg BA markedly reduced serum aminotransferase activities, protected hepatoycte apoptosis and reduced the increase of plasma cytokine levels, including tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma) and interleukin-6 (IL-6). Furthermore, BA pretreatment decreased tissue myeloperoxidase activity and lipid peroxidation, but increased the superoxide dismutase level. In vitro studies indicated that the beneficial effect of BA was associated with reduced cytokine production from lymphocytes and reduced TNF-alpha-induced hepatocyte apoptosis. Conclusion: These results suggest that BA has therapeutic potential for T-cell-mediated liver injury. |
| WOS关键词 | TUMOR-NECROSIS-FACTOR ; TNF-ALPHA ; INDUCED HEPATITIS ; REACTIVE OXYGEN ; CELL INJURY ; T-CELLS ; MICE ; ROLES ; MECHANISMS ; COMPONENTS |
| WOS研究方向 | Gastroenterology & Hepatology |
| 语种 | 英语 |
| WOS记录号 | WOS:000245412900018 |
| 出版者 | BLACKWELL PUBLISHING |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273275]  |
| 专题 | 药物安全性评价中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ren, Jin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Lin-lin,Gong, Li-kun,Wang, Hui,et al. Baicalin protects mouse from Concanavalin A-induced liver injury through inhibition of cytokine production and hepatocyte apoptosis[J]. LIVER INTERNATIONAL,2007,27(4):582-591. |
| APA | Liu, Lin-lin.,Gong, Li-kun.,Wang, Hui.,Xiao, Ying.,Wu, Xiong-fei.,...&Ren, Jin.(2007).Baicalin protects mouse from Concanavalin A-induced liver injury through inhibition of cytokine production and hepatocyte apoptosis.LIVER INTERNATIONAL,27(4),582-591. |
| MLA | Liu, Lin-lin,et al."Baicalin protects mouse from Concanavalin A-induced liver injury through inhibition of cytokine production and hepatocyte apoptosis".LIVER INTERNATIONAL 27.4(2007):582-591. |
入库方式： OAI收割
来源：上海药物研究所
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