Isolation of chlorogenic acids and their derivatives from Stemona japonica by preparative HPLC and evaluation of their anti-AIV (H5N1) activity in vitro
文献类型：期刊论文
| 作者 | Ge, Fan; Ke, Changqiang ; Tang, Wei; Yang, Xinzhou; Tang, Chunping; Qin, Guowei; Xu, Rensheng; Li, Tianxian; Chen, Xinwen; Zuo, Jianping
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| 刊名 | PHYTOCHEMICAL ANALYSIS
 |
| 出版日期 | 2007-05 |
| 卷号 | 18期号:3页码:213-218 |
| 关键词 | chlorogenic acids Stemona japonica preparative HPLC Anti-AIV (H5NI) activity |
| ISSN号 | 0958-0344 |
| DOI | 10.1002/pca.974 |
| 文献子类 | Article |
| 英文摘要 | Two chlorogenic acids and five chlorogenic acid derivatives were simultaneously separated and purified from Stemona japonica by preparative high-performance liquid chromatography. Five of the collected compounds were over 95% pure while the other two compounds were over 90% pure. Their structures were elucidated as 3-O-feruloylquinic acid (1), 4-O-feruloylquinic acid (2), methyl 3-O-feruloylquinate (3), methyl 5-O-caffeyolquinate (4), methyl 4-O-feruloylquinate (5), ethyl 3-O-feruloylquinate (6) and the new compound ethyl 4-O-feruloylquinate (7) by UV, NMR and ESI-MS. All compounds were obtained from Stemona species for the first time, however compounds 6 and 7 are believed to be artefacts from the ethanol extraction. The anti-AIV (H5N1) activities were evaluated by Neutral Red uptake assay. Compounds 3 and 4 exerted moderate inhibitory effect against AIV (H5N1) in vitro. Copyright (c) 2007 John Wiley & Sons, Ltd. |
| WOS关键词 | QUINIC ACID ; SEPARATION ; CHROMATOGRAPHY ; CONSTITUENTS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000246163300006 |
| 出版者 | JOHN WILEY & SONS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273278]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ye, Yang |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ge, Fan,Ke, Changqiang,Tang, Wei,et al. Isolation of chlorogenic acids and their derivatives from Stemona japonica by preparative HPLC and evaluation of their anti-AIV (H5N1) activity in vitro[J]. PHYTOCHEMICAL ANALYSIS,2007,18(3):213-218. |
| APA | Ge, Fan.,Ke, Changqiang.,Tang, Wei.,Yang, Xinzhou.,Tang, Chunping.,...&Ye, Yang.(2007).Isolation of chlorogenic acids and their derivatives from Stemona japonica by preparative HPLC and evaluation of their anti-AIV (H5N1) activity in vitro.PHYTOCHEMICAL ANALYSIS,18(3),213-218. |
| MLA | Ge, Fan,et al."Isolation of chlorogenic acids and their derivatives from Stemona japonica by preparative HPLC and evaluation of their anti-AIV (H5N1) activity in vitro".PHYTOCHEMICAL ANALYSIS 18.3(2007):213-218. |
入库方式： OAI收割
来源：上海药物研究所
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