Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors
文献类型：期刊论文
| 作者 | Zhang, Li; Qiu, Beiying; Xiong, Bing ; Li, Xin; Li, Jingya; Wang, Xin; Li, Jia; Shen, Jingkang
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2007-04-15 |
| 卷号 | 17期号:8页码:2118-2122 |
| 关键词 | JSP-1 inhibitor quinoxalinylurea |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2007.01.094 |
| 文献子类 | Article |
| 英文摘要 | A series of quinoxalinylurea-based inhibitors are synthesized and shown to be the novel and potent inhibitors against Jnk Stimulatory Phosphatase-1 (JSP-1), which is a special member of dual-specificity protein phosphatase (DSP) family. Biological assay and computational modeling studies showed the compounds were reversible and noncompetitive inhibitors of JSP-1. JSP-1 inhibitors may be useful for the treatment of inflammatory, vascular, neurodegenerative, metabolic, and oncological diseases in humans associated with dysfunctional Jnk signaling. (c) 2007 Elsevier Ltd. All rights reserved. |
| WOS关键词 | PROTEIN-TYROSINE PHOSPHATASES ; DUAL-SPECIFICITY PHOSPHATASE ; II RECEPTOR ANTAGONISTS ; BIOLOGICAL PROPERTIES ; DRUG TARGETS ; JNK ; PATHWAY ; FAMILY ; ACID |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000246045900001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273284]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物化学研究室 |
| 通讯作者 | Li, Jia |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Natl Ctr Drug Screening, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Li,Qiu, Beiying,Xiong, Bing,et al. Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(8):2118-2122. |
| APA | Zhang, Li.,Qiu, Beiying.,Xiong, Bing.,Li, Xin.,Li, Jingya.,...&Shen, Jingkang.(2007).Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,17(8),2118-2122. |
| MLA | Zhang, Li,et al."Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17.8(2007):2118-2122. |
入库方式： OAI收割
来源：上海药物研究所
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