Unique nucleotide polymorphism of ankyrin gene cluster in Arabidopsis
文献类型：期刊论文
| 作者 | Du, Jianchang; Wang, Xingna; Zhang, Mingsheng; Tian, Dacheng; Yang, Yong-Hua |
| 刊名 | JOURNAL OF GENETICS
 |
| 出版日期 | 2007-04 |
| 卷号 | 86期号:1页码:27-35 |
| 关键词 | ankyrin gene cluster divergence evolution gene duplication Arabidopsis |
| ISSN号 | 0022-1333 |
| DOI | 10.1007/s12041-007-0004-0 |
| 文献子类 | Article |
| 英文摘要 | The ankyrin (ANK) gene cluster is a part of a multigene family encoding ANK transmembrane proteins in Arabidopsis thaliana, and plays an important role in protein-protein interactions and in signal pathways. In contrast to other regions of a genome, the ANK gene cluster exhibits an extremely high level of DNA polymorphism in an similar to 5-kb region, without apparent decay. Phylogenetic analysis detects two clear, deeply differentiated haplotypes (dimorphism). The divergence between haplotypes of accession Col-0 and Ler-0 (Hap-C and Hap-L) is estimated to be 10.7%, approximately equal to the 10.5% average divergence between A. thaliana and A. lyrata. Sequence comparisons for the ANK gene cluster homologues in Col-0 indicate that the members evolve independently, and that the similarity among paralogues is lower than between alleles. Very little intralocus recombination or gene conversion is detected in ANK regions. All these characteristics of the ANK gene cluster are consistent with a tandem gene duplication and birth-and-death process. The possible mechanisms for and implications of this elevated nucleotide variation are also discussed, including the suggestion of balancing selection. |
| WOS关键词 | DEATH PROCESS ; DNA POLYMORPHISM ; PURIFYING SELECTION ; MULTIGENE FAMILIES ; RESISTANCE GENES ; EVOLUTION ; THALIANA ; LOCUS ; RECOMBINATION ; DIVERGENCE |
| WOS研究方向 | Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000248375900004 |
| 出版者 | INDIAN ACADEMY SCIENCES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273295]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Yang, Yong-Hua |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Discovery & Design, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Nanjing Univ, Dept Biol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Jianchang,Wang, Xingna,Zhang, Mingsheng,et al. Unique nucleotide polymorphism of ankyrin gene cluster in Arabidopsis[J]. JOURNAL OF GENETICS,2007,86(1):27-35. |
| APA | Du, Jianchang,Wang, Xingna,Zhang, Mingsheng,Tian, Dacheng,&Yang, Yong-Hua.(2007).Unique nucleotide polymorphism of ankyrin gene cluster in Arabidopsis.JOURNAL OF GENETICS,86(1),27-35. |
| MLA | Du, Jianchang,et al."Unique nucleotide polymorphism of ankyrin gene cluster in Arabidopsis".JOURNAL OF GENETICS 86.1(2007):27-35. |
入库方式： OAI收割
来源：上海药物研究所
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