Insulin-sensitizing effects of a novel alpha-methyl-alpha-phenoxylpropionate derivative in vitro
文献类型：期刊论文
| 作者 | Wu, Hao-shu; Yu, Juan-hong; Li, Ying-yin; Yang, Yu-she ; He, Qiao-jun; Lou, Yi-jia; Ji, Ru-yun
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2007-03 |
| 卷号 | 28期号:3页码:417-422 |
| 关键词 | YY20 peroxisome proliferator-activated receptor gamma insulin sensitivity glucose consumption |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2007.00506.x |
| 文献子类 | Article |
| 英文摘要 | Aim: To examine the insulin sensitizing effects of a novel alpha-methyl-alpha-phenoxylpropionate derivative YY20 in insulin-sensitive cell lines. Methods: The peroxisome proliferator-activated receptor gamma (PPAR gamma) agonist bioactivities of YY20 were detected by a preadipocyte differentiation assay. RT-PCR and Western blotting analysis were used to detect the expression of the target gene or protein. The effects of YY20 on insulin-mediated glucose consumption were determined in the HepG2 human hepatocellular carcinoma line. Results: YY20 could enhance the differentiation of preadipocytes to adipocytes and upregulate the gene expression of PPAR gamma(2), as well as the protein expression of insulin receptor sub-strate-1 (IRS-1), glucose transporter-4 (GLUT4), and adiponectin (ACRP30). The effects on GLUT4 and ACRP30 could be reversed by the PPAR gamma inhibitor SR-202. Furthermore, YY20 efficiently reduced glucose consumptions in HepG2 cells after 24 h culture, and the effects were related to insulin and YY20 concentrations. Conclusion: YY20, a potential insulin-sensitizing agent like rosiglitazone, could enhance glucose consumption in HepG2 cells in a concentration- and insulin-dependent manner. It may improve the insulin resistance associated with type 2 diabetes. |
| WOS关键词 | GLUCOSE ; GAMMA ; ROSIGLITAZONE ; ADIPOGENESIS ; TROGLITAZONE ; FIBROBLASTS ; ADIPOCYTES ; CONVERSION ; AGONISTS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:2670892 |
| WOS记录号 | WOS:000244418000015 |
| 出版者 | BLACKWELL PUBLISHING |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273309]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Lou, Yi-jia |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Shanghai Inst Mat Med,State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Zhejiang Univ, Coll Pharmaceut Sci, Dept Pharmacol & Toxicol, Hangzhou 310058, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Hao-shu,Yu, Juan-hong,Li, Ying-yin,et al. Insulin-sensitizing effects of a novel alpha-methyl-alpha-phenoxylpropionate derivative in vitro[J]. ACTA PHARMACOLOGICA SINICA,2007,28(3):417-422. |
| APA | Wu, Hao-shu.,Yu, Juan-hong.,Li, Ying-yin.,Yang, Yu-she.,He, Qiao-jun.,...&Ji, Ru-yun.(2007).Insulin-sensitizing effects of a novel alpha-methyl-alpha-phenoxylpropionate derivative in vitro.ACTA PHARMACOLOGICA SINICA,28(3),417-422. |
| MLA | Wu, Hao-shu,et al."Insulin-sensitizing effects of a novel alpha-methyl-alpha-phenoxylpropionate derivative in vitro".ACTA PHARMACOLOGICA SINICA 28.3(2007):417-422. |
入库方式： OAI收割
来源：上海药物研究所
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