Laser Doppler flowmetry for assessment of myocardial microperfusion in the beating rat heart
文献类型：期刊论文
| 作者 | Li, Xiao-Fen; Wang, Yi-Ping
|
| 刊名 | VASCULAR PHARMACOLOGY
 |
| 出版日期 | 2007-03 |
| 卷号 | 46期号:3页码:207-214 |
| 关键词 | myocardial microperfusion laser Doppler flowmetry captopril nifedipine pituitrin |
| ISSN号 | 1537-1891 |
| DOI | 10.1016/j.vph.2006.10.003 |
| 文献子类 | Article |
| 英文摘要 | Although laser Doppler flowmetry (LDF) is widely used for measuring microperfusion, it is rarely used to measure coronary microcirculation. The present in vivo study investigated the use of LDF to measure myocardial microperfusion in beating rat hearts. Ascending aortic flow and other hemodynamic parameters were simultaneously recorded. A needle probe with a holder was adhered to the epicardium of the left ventricular myocardium close to the left anterior descending coronary artery in an anaesthetized open-chest rat. Myocardial microperfusion was measured in response to bolus intravenous administration of both two representative vasodilators (captopril and nifedipine) and a vasoconstrictor (pituitrin). Myocardial microperfusion was found to be predominately diastolic, and in an opposing phase to the ascending aortic flow. Captopril (5 or 10 mg/kg) increased the initial myocardial microperfusion phase. Nifedipine at 75 mu g/kg caused a sustained myocardial microperfusion elevation with a peak increase of 7.1 +/- 1.1%, but this was not observed using 150 mu g/kg nifedipine. Both drugs caused an increase in the cardiac index. In contrast, myocardial microperfusion decreased (28.7 +/- 0.1% maximum decrease) in response to I IU/kg pituitrin. In conclusion, LDF provided a means of assessing myocardial microperfusion in beating rat hearts, and can be applied to evaluate the coronary microcirculation response to drugs. (c) 2006 Published by Elsevier Inc. |
| WOS关键词 | BLOOD-FLOW ; PORCINE HEART ; PERFUSION ; NIFEDIPINE ; MICROCIRCULATION ; HEMODYNAMICS ; MICROVESSELS ; INFARCTION ; VENTRICLE ; INFLOW |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000244086600009 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273318]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Yi-Ping |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 2.Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiao-Fen,Wang, Yi-Ping. Laser Doppler flowmetry for assessment of myocardial microperfusion in the beating rat heart[J]. VASCULAR PHARMACOLOGY,2007,46(3):207-214. |
| APA | Li, Xiao-Fen,&Wang, Yi-Ping.(2007).Laser Doppler flowmetry for assessment of myocardial microperfusion in the beating rat heart.VASCULAR PHARMACOLOGY,46(3),207-214. |
| MLA | Li, Xiao-Fen,et al."Laser Doppler flowmetry for assessment of myocardial microperfusion in the beating rat heart".VASCULAR PHARMACOLOGY 46.3(2007):207-214. |
入库方式： OAI收割
来源：上海药物研究所
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