Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury
文献类型：期刊论文
| 作者 | Wang, Zhi Fei; Tang, Xi Can |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2007-02-20 |
| 卷号 | 581期号:4页码:596-602 |
| 关键词 | huperzine A acetylcholinesterase inhibitor oxygen-glucose deprivation cholinergic anti-inflammatory pathway alpha 7 nicotinic acetylcholine receptor |
| ISSN号 | 1873-3468 |
| DOI | 10.1016/j.febslet.2007.01.016 |
| 文献子类 | Article |
| 英文摘要 | The protective effects of huperzine A against oxygenglucose deprivation (OGD)-induced injury in C6 cells were investigated. OGD for 6 h and reoxygenation for 6 h enhanced phosphorylation and degradation of I kappa B alpha and nuclear translocation of nuclear factor-kappa B (NF-kappa B), triggered overexpression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and nitric oxide (NO) in C6 cells. Along with inhibiting acety1cholinesterase activity, treatment with 1 mu M huperzine A inhibited activation of NF-kappa B, attenuated iNOS, COX-2 and NO overexpression, and promoted survival in C6 cells subjected to OGD insult. The protective effects of huperzine A were partly mediated by "cholinergic anti-inflammatory pathway" through alpha 7 nicotinic acetylcholine receptor. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| WOS关键词 | NITRIC-OXIDE SYNTHASE ; TRANSIENT CEREBRAL-ISCHEMIA ; FACTOR-KAPPA-B ; ACETYLCHOLINESTERASE INHIBITORS ; ALZHEIMERS-DISEASE ; CHOLINESTERASE-INHIBITORS ; VASCULAR DEMENTIA ; BRAIN-INJURY ; CYCLOOXYGENASE-2 ; INFLAMMATION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000244572300003 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273321]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Tang, Xi Can |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zhi Fei,Tang, Xi Can. Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury[J]. FEBS LETTERS,2007,581(4):596-602. |
| APA | Wang, Zhi Fei,&Tang, Xi Can.(2007).Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury.FEBS LETTERS,581(4),596-602. |
| MLA | Wang, Zhi Fei,et al."Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury".FEBS LETTERS 581.4(2007):596-602. |
入库方式： OAI收割
来源：上海药物研究所
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