Pharmacokinetics, tissue distribution, metabolism, and excretion of depside salts from Salvia miltiorrhiza in rats
文献类型：期刊论文
| 作者 | Li, Xiaochuan; Yu, Chen; Lu, Youli; Gu, Yunlong; Lu, Jie; Xu, Wei; Xuan, Lijiang ; Wang, Yiping
|
| 刊名 | DRUG METABOLISM AND DISPOSITION
 |
| 出版日期 | 2007-02 |
| 卷号 | 35期号:2页码:234-239 |
| ISSN号 | 0090-9556 |
| DOI | 10.1124/dmd.106.013045 |
| 文献子类 | Article |
| 英文摘要 | Salviae miltiorrhiza, a traditional Chinese medical herb known as "Danshen," has been widely used in clinics to improve blood circulation, relieve blood stasis, and treat coronary heart disease. Depside salts from S. miltiorrhiza are a novel drug in which magnesium lithospermate B and its analogs are the active components. The pharmacokinetics, tissue distribution, metabolism, and excretion of three of the major components, lithospermic acid B, rosmarinic acid ( RA), and lithospermic acid ( LA), were studied by liquid chromatography-tandem mass spectrometry following intravenous administration in Sprague-Dawley rats. The elimination half-lives for LSB, RA, and LA were 1.04, 0.75, and 2.0 h, respectively, when 60 mg/kg S. miltiorrhiza depside salts were administrated. The areas under the curve for LSB, RA, and LA were 51.6, 6.6, and 25.2 mg center dot h/l, respectively, and the values decreased in the individual tissues in the following order: kidney > lung > liver > heart > spleen > brain for LSB; kidney > lung > heart > liver > spleen > brain for RA; and heart > lung > kidney > liver > spleen > brain for LA. After intravenous administration of 60 mg/kg S. miltiorrhiza depside salts, 86% of the LSB was excreted in the bile within 6 h. The main metabolites M1 and M2 were found in the serum. Overall, the results show that depside salts from S. miltiorrhiza are rapidly and widely distributed to tissues after intravenous administration in rats but that they are also rapidly cleared and excreted. |
| WOS关键词 | MAGNESIUM LITHOSPERMATE-B ; ROSMARINIC ACID ; MASS-SPECTROMETRY ; URINARY-EXCRETION ; RENAL-FAILURE ; CAFFEIC ACID ; POTENT |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000243685000009 |
| 出版者 | AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273337]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Yiping |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Shanghai Xuhui Cent Hosp, Cent Lab, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiaochuan,Yu, Chen,Lu, Youli,et al. Pharmacokinetics, tissue distribution, metabolism, and excretion of depside salts from Salvia miltiorrhiza in rats[J]. DRUG METABOLISM AND DISPOSITION,2007,35(2):234-239. |
| APA | Li, Xiaochuan.,Yu, Chen.,Lu, Youli.,Gu, Yunlong.,Lu, Jie.,...&Wang, Yiping.(2007).Pharmacokinetics, tissue distribution, metabolism, and excretion of depside salts from Salvia miltiorrhiza in rats.DRUG METABOLISM AND DISPOSITION,35(2),234-239. |
| MLA | Li, Xiaochuan,et al."Pharmacokinetics, tissue distribution, metabolism, and excretion of depside salts from Salvia miltiorrhiza in rats".DRUG METABOLISM AND DISPOSITION 35.2(2007):234-239. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。