Recent developments in studies of l-stepholidine and its analogs: Chemistry, pharmacology and clinical implications
文献类型：期刊论文
| 作者 | Mo, Jiao; Guo, Yang; Yang, Yu-She ; Shen, Jing-Shan; Jin, Guo-Zhang; Zhen, Xuechu
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| 刊名 | CURRENT MEDICINAL CHEMISTRY
 |
| 出版日期 | 2007 |
| 卷号 | 14期号:28页码:2996-3002 |
| 关键词 | tetrahydroprotoberberines l-stepholidine dopamine receptor schizophrenia agonist antagonist |
| ISSN号 | 0929-8673 |
| DOI | 10.2174/092986707782794050 |
| 文献子类 | Review |
| 英文摘要 | Tetrahydroprotoberberines (THPBs) represent a series of compounds extracted from the Chinese herb Corydalis ambigua and various species of Stephania. THPBs, dependent on the presence of hydroxyl groups in its structure, are divided into three types: nonhydroxyl-THPBs, monohydroxyl-THPBs and dihydroxyl-THPBs. THPBs are identified as a new category of dopamine receptor ligands. Among all THPBs, dihydroxyl-THPBs attracted particular attention because of their dual actions on dopamine (DA) receptors. They exhibit D-1 receptor agonistic activity while acting as D-2 receptor antagonists. This unique pharmacological profile made dihydroxyl-THPBs such as l-stepholidine (l-SPD) potential agents in the treatment of drug addiction, Parkinson's disease, and especially, schizophrenia. Clinical studies have shown that co-administration of l-SPD with a typical antipsychotic drug significantly enhances the therapeutic effects and remarkably reduces the tardive dyskinesia induced by the typical antipsychotic drug used with schizophrenic patients. Moreover, l-SPD alone was shown to have therapeutic value without inducing significant extrapyramidal side effects and also seemed to reduce the negative symptoms of schizophrenia. This is confirmed in experimental studies using animal models of schizophrenia, in which l-SPD improved social interaction and cognitive function, inhibited hyperactivity in schizophrenic animals. This review discusses the chemistry, pharmacology and clinical implications of l-THPBs in the drug development for psychosis and neurobiological diseases. |
| WOS关键词 | DOPAMINE-RECEPTORS ; FIRING ACTIVITY ; LESIONED RATS ; 12-CHLOROSCOULERINE ENANTIOMERS ; D-2 RECEPTORS ; CALF STRIATUM ; (-)-STEPHOLIDINE ; NEURONS ; AGONIST ; TETRAHYDROPROTOBERBERINES |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000253578700007 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273375]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhen, Xuechu |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mo, Jiao,Guo, Yang,Yang, Yu-She,et al. Recent developments in studies of l-stepholidine and its analogs: Chemistry, pharmacology and clinical implications[J]. CURRENT MEDICINAL CHEMISTRY,2007,14(28):2996-3002. |
| APA | Mo, Jiao,Guo, Yang,Yang, Yu-She,Shen, Jing-Shan,Jin, Guo-Zhang,&Zhen, Xuechu.(2007).Recent developments in studies of l-stepholidine and its analogs: Chemistry, pharmacology and clinical implications.CURRENT MEDICINAL CHEMISTRY,14(28),2996-3002. |
| MLA | Mo, Jiao,et al."Recent developments in studies of l-stepholidine and its analogs: Chemistry, pharmacology and clinical implications".CURRENT MEDICINAL CHEMISTRY 14.28(2007):2996-3002. |
入库方式： OAI收割
来源：上海药物研究所
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