The neuropharmacology of (-)-stepholidine and its potential applications
文献类型：期刊论文
| 作者 | Yang, Kechun1,2,3; Jin, Guozhang3 ; Wu, Jie1,2
|
| 刊名 | CURRENT NEUROPHARMACOLOGY
 |
| 出版日期 | 2007 |
| 卷号 | 5期号:4页码:289-294 |
| 关键词 | stepholidine dopamine D1 receptor dopamine D2 receptor schizophrenia Parkinson's disease |
| ISSN号 | 1570-159X |
| DOI | 10.2174/157015907782793649 |
| 文献子类 | Article |
| 英文摘要 | (-)-Stepholidine (SPD), a natural product isolated from the Chinese herb Stephania, possesses dopamine (DA) D1 partial agonistic and D2 antagonistic properties in the nigrostriatal and mesocorticolimbic DAergic pathways. These unique dual effects have suggested that SPD can effectively restore previously imbalanced functional linkage between D1 and D2 receptors under schizophrenic conditions, in which, SPD improves both the negative and positive symptoms of schizophrenia. SPD also relieves the motor symptoms of Parkinson's disease (PD) when co-administered with Levodopa. Furthermore, SPD exhibits neuroprotective effects through an antioxidative mechanism and slows down the progression of neuronal degeneration in the substantia nigra (SN) of PD patients and/or animal models. Therefore, SPD is a novel, natural compound with potentially therapeutic roles in the treatment of schizophrenia and/or PD. |
| WOS关键词 | D2 DOPAMINE-RECEPTORS ; SPONTANEOUSLY HYPERTENSIVE-RATS ; HYDROXYL FREE-RADICALS ; L-STEPHOLIDINE ; 6-HYDROXYDOPAMINE-LESIONED RATS ; PARKINSONS-DISEASE ; NUCLEUS-ACCUMBENS ; CORPUS STRIATUM ; FIRING ACTIVITY ; ROTATIONAL BEHAVIOR |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000253592500007 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273376]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wu, Jie |
| 作者单位 | 1.St Josephs Hosp, Barrow Neurol Inst, Div Neurol, Phoenix, AZ 85013 USA; 2.Med Ctr, Phoenix, AZ 85013 USA; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res,Dept Pharmacol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Kechun,Jin, Guozhang,Wu, Jie. The neuropharmacology of (-)-stepholidine and its potential applications[J]. CURRENT NEUROPHARMACOLOGY,2007,5(4):289-294. |
| APA | Yang, Kechun,Jin, Guozhang,&Wu, Jie.(2007).The neuropharmacology of (-)-stepholidine and its potential applications.CURRENT NEUROPHARMACOLOGY,5(4),289-294. |
| MLA | Yang, Kechun,et al."The neuropharmacology of (-)-stepholidine and its potential applications".CURRENT NEUROPHARMACOLOGY 5.4(2007):289-294. |
入库方式： OAI收割
来源：上海药物研究所
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