Syntheses of (15R,16R,19R,20S,34S) and (15S,16S,19S,20R,34S) aza-solamin
文献类型：期刊论文
| 作者 | Meng, Wang; Shen Jing-Kang |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2006-12-10 |
| 卷号 | 27期号:12页码:2324-2328 |
| 关键词 | aza-solamin Annonaceous acetogenin coupling reaction |
| ISSN号 | 0251-0790 |
| 文献子类 | Article |
| 英文摘要 | A convergent synthesis of two possible diastereomers of aza-solamin (threo-trans-erythro) (2a and 2b), which possessed pyrrolidine ring in place of THF ring of solamm, was accomplished. The key building block 5a and 9a were originated from chrial starting material. The stereochemistry of pyrrolidine core unit was determined by H-1 NMR spectroscopic analysis. The preliminary results of in vitro test against A-549 and HCT-116 cell lines show that both compounds have almost the same activity. |
| WOS关键词 | MITOCHONDRIAL COMPLEX-I ; ANNONACEOUS ACETOGENINS ; POTENT ANTITUMOR ; RECENT PROGRESS ; ANALOG ; DERIVATIVES ; INHIBITORS ; FRAGMENT ; MIMICRY ; CHAIN |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2642655 |
| WOS记录号 | WOS:000242962700020 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273425]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Shen Jing-Kang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Meng, Wang,Shen Jing-Kang. Syntheses of (15R,16R,19R,20S,34S) and (15S,16S,19S,20R,34S) aza-solamin[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2006,27(12):2324-2328. |
| APA | Meng, Wang,&Shen Jing-Kang.(2006).Syntheses of (15R,16R,19R,20S,34S) and (15S,16S,19S,20R,34S) aza-solamin.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,27(12),2324-2328. |
| MLA | Meng, Wang,et al."Syntheses of (15R,16R,19R,20S,34S) and (15S,16S,19S,20R,34S) aza-solamin".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 27.12(2006):2324-2328. |
入库方式： OAI收割
来源：上海药物研究所
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