Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution
文献类型：期刊论文
| 作者 | Zhang, Li; Qiu, Beiying; Li, Xin; Wang, Xin ; Li, Jingya; Zhang, Yongliang; Liu, Jian; Li, Jia; Shen, Jingkang
|
| 刊名 | MOLECULES
 |
| 出版日期 | 2006-12 |
| 卷号 | 11期号:12页码:988-999 |
| 关键词 | microwave irradiation nucleophilic substitution 6-substituted quinoxalines JSP-1 |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/11120988 |
| 文献子类 | Article |
| 英文摘要 | A small library of 6-aminoquinoxalines has been prepared by nucleophilic substitution of 6-fluoroquinoxaline with amines and nitrogen-containing heterocycles under computer-controlled microwave irradiation. Some compounds were found to be potent inhibitors of JNK Stimulatory Phosphatase-1 (JSP-1) in an in vitro biological assay. |
| WOS关键词 | RECEPTOR ANTAGONISTIC ACTIVITY ; DUAL-SPECIFICITY PHOSPHATASE ; BIOLOGICAL PROPERTIES ; ORGANIC-SYNTHESIS ; PHENYL GROUP ; DERIVATIVES ; CHEMISTRY ; ACID ; JNK ; 5-AMINOMETHYLQUINOXALINE-2,3-DIONES |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000243402400006 |
| 出版者 | MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273438]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物化学研究室 |
| 通讯作者 | Shen, Jingkang |
| 作者单位 | 1.Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Li,Qiu, Beiying,Li, Xin,et al. Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution[J]. MOLECULES,2006,11(12):988-999. |
| APA | Zhang, Li.,Qiu, Beiying.,Li, Xin.,Wang, Xin.,Li, Jingya.,...&Shen, Jingkang.(2006).Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution.MOLECULES,11(12),988-999. |
| MLA | Zhang, Li,et al."Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution".MOLECULES 11.12(2006):988-999. |
入库方式： OAI收割
来源：上海药物研究所
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