4 '-Alkoxyl substitution enhancing the anti-mitotic effect of 5-(3 ',4 ',5 '-substituted)anilino-4-hydroxy-8-nitroquinazolines as a novel class of anti-microtubule agents
文献类型：期刊论文
| 作者 | Jin, Yi ; Zhou, Zu-Yu; Tian, Wei; Yu, Qiang; Long, Ya-Qiu
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2006-11-15 |
| 卷号 | 16期号:22页码:5864-5869 |
| 关键词 | quinazoline mitosis inhibitor tubulin polymerization anti-microtubule agent alkoxyl substitution aniline antiproliferative effect cell cycle tumor cells |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2006.08.058 |
| 文献子类 | Article |
| 英文摘要 | Mitosis inhibitors are powerful anticancer drugs. Based on a novel anti-microtubule agent of 5-(4'-methoxy)anilino-4-hydroxy-8-nitroquinazoline, a series of 5-(3',4',5'-substituted)anilino-4-hydroxy-8- nitroquinazolines were designed and synthesized to investigate the effect of the substitution on the inhibitory activity against mitotic progression of tumor cells. The large alkoxyl substitution on the 4'-position of 5-anilino ring is beneficial for the potency. The 5-(3',4,5'-trimethoxy)anilino-8-nitroquinazoline (1h) displays an overwhelming activity in arresting the cells at the G2/M phase, providing a promising new template for further development of potent microtubule-targeted anti-mitotic drugs. (c) 2006 Elsevier Ltd. All rights reserved. |
| WOS关键词 | INHIBITORS ; RESISTANCE ; MECHANISMS ; CANCER |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000241850400032 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273443]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Long, Ya-Qiu |
| 作者单位 | 1.Shenyang Pharmaceutb Univ, Sch Pharmaceut Engn, Liaoning 110016, India 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Yi,Zhou, Zu-Yu,Tian, Wei,et al. 4 '-Alkoxyl substitution enhancing the anti-mitotic effect of 5-(3 ',4 ',5 '-substituted)anilino-4-hydroxy-8-nitroquinazolines as a novel class of anti-microtubule agents[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2006,16(22):5864-5869. |
| APA | Jin, Yi,Zhou, Zu-Yu,Tian, Wei,Yu, Qiang,&Long, Ya-Qiu.(2006).4 '-Alkoxyl substitution enhancing the anti-mitotic effect of 5-(3 ',4 ',5 '-substituted)anilino-4-hydroxy-8-nitroquinazolines as a novel class of anti-microtubule agents.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,16(22),5864-5869. |
| MLA | Jin, Yi,et al."4 '-Alkoxyl substitution enhancing the anti-mitotic effect of 5-(3 ',4 ',5 '-substituted)anilino-4-hydroxy-8-nitroquinazolines as a novel class of anti-microtubule agents".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16.22(2006):5864-5869. |
入库方式： OAI收割
来源：上海药物研究所
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