Syntheses of triazole-modified zanamivir analogues via click chemistry and anti-AIV activities
文献类型：期刊论文
| 作者 | Li, Jian; Zheng, Mingyue ; Tang, Wei; He, Pei-Lan; Zhu, Weiliang; Li, Tianxian; Zuo, Jian-Ping; Liu, Hong; Jiang, Hualiang
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2006-10-01 |
| 卷号 | 16期号:19页码:5009-5013 |
| 关键词 | zanamivir analogues avian influenza virus click chemistry molecular modeling |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2006.07.047 |
| 文献子类 | Article |
| 英文摘要 | Sixteen novel 4-triazole-modified zanamivir (1) analogues were synthesized using the click reactions, and their inhibitory activities against avian influenza virus (AIV, H5N1) were determined. Compound 3b exerts promising inhibitory activity with EC50 of 6.4 mu M, which is very close to that of zanamivir (EC50 = 2.8 mu M). Molecular modeling provided the information about the binding model between inhibitors and neuraminidase, which are in good agreement with inhibitory activities. (c) 2006 Elsevier Ltd. All rights reserved. |
| WOS关键词 | INFLUENZA NEURAMINIDASE INHIBITORS ; ANTIINFLUENZA VIRUS ACTIVITY ; AVIAN INFLUENZA ; ACID ; DERIVATIVES ; SIALIDASE ; SERIES ; DISCOVERY ; POTENT ; H5N1 |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000240615400005 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273479]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物发现与设计中心 药物化学研究室 |
| 通讯作者 | Zuo, Jian-Ping |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai Inst Mat Med,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai Inst Mat Med,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China 4.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jian,Zheng, Mingyue,Tang, Wei,et al. Syntheses of triazole-modified zanamivir analogues via click chemistry and anti-AIV activities[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2006,16(19):5009-5013. |
| APA | Li, Jian.,Zheng, Mingyue.,Tang, Wei.,He, Pei-Lan.,Zhu, Weiliang.,...&Jiang, Hualiang.(2006).Syntheses of triazole-modified zanamivir analogues via click chemistry and anti-AIV activities.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,16(19),5009-5013. |
| MLA | Li, Jian,et al."Syntheses of triazole-modified zanamivir analogues via click chemistry and anti-AIV activities".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16.19(2006):5009-5013. |
入库方式： OAI收割
来源：上海药物研究所
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