Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus
文献类型：期刊论文
| 作者 | Gao, Zhao-Bing ; Chen, Xue-Qin; Hu, Guo-Yuan
|
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2006-09-21 |
| 卷号 | 1111页码:41-47 |
| 关键词 | excitatory synaptic transmission glutamate hippocampus neuroprotection paired-pulse facilitation trans-resveratrol |
| ISSN号 | 0006-8993 |
| DOI | 10.1016/j.brainres.2006.06.096 |
| 文献子类 | Article |
| 英文摘要 | The red wine polyphenol trans-resveratrol has been found to exert potent protective actions in a variety of cerebral ischemia models. The neuroprotection by trans-resveratrol thus far is mainly attributed to its intrinsic antioxidant properties. In the present study, the effects of the red wine polyphenol on excitatory synaptic transmission were investigated in the CA1 region of rat hippocampal slices. Perfusion with trans-resveratrol (10-100 mu M) caused a concentration-dependent inhibition on the filed excitatory postsynaptic potentials (the field EPSPs) without detectable effect on the presynaptic volleys. The inhibition had a slow onset and was reversible. Trans-resveratrol (30 mu M) did not change the ratios of paired-pulse facilitation of the field EPSPs tested at intervals of 20, 40 and 80 ms, nor did it alter the membrane properties of postsynaptic CA1 pyramidal neurons. However, trans-resveratrol (30 mu M) significantly suppressed glutamate-induced currents in postsynaptic CA1 pyramidal neurons. In dissociated hippocampal neurons, the IC50 value of trans-resveratrol in inhibition of glutamate-induced currents was 53.3 +/- 9.4 mu M. Kainite and NMDA receptors were more sensitive to the red wine polyphenol than AMPA receptors. The present study for the first time demonstrates that trans-resveratrol inhibits the postsynaptic glutamate receptors, which probably works in concert with its antioxidant action for ameliorating the brain ischemic injury. The findings also support the future use of trans-resvelatrol in the treatment of various neurodegenerative disorders. (c) 2006 Elsevier B.V. All rights reserved. |
| WOS关键词 | PROTEIN-KINASE-C ; RED WINE INGREDIENT ; OXIDATIVE STRESS ; NEURODEGENERATIVE DISORDERS ; VENTRICULAR MYOCYTES ; NEURONS ; NEUROTOXICITY ; CELLS ; MODULATION ; PROTECTION |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000240905200006 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273491]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 神经药理学研究国际科学家工作站 |
| 通讯作者 | Hu, Guo-Yuan |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Materia Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Zhao-Bing,Chen, Xue-Qin,Hu, Guo-Yuan. Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus[J]. BRAIN RESEARCH,2006,1111:41-47. |
| APA | Gao, Zhao-Bing,Chen, Xue-Qin,&Hu, Guo-Yuan.(2006).Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus.BRAIN RESEARCH,1111,41-47. |
| MLA | Gao, Zhao-Bing,et al."Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus".BRAIN RESEARCH 1111(2006):41-47. |
入库方式： OAI收割
来源：上海药物研究所
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