Potentiation of adenosine A(1) receptor agonist CPA-induced antinociception by paeoniflorin in mice
文献类型：期刊论文
| 作者 | Liu, Da-Zhi; Zhao, Fei-Li; Liu, Jing; Ji, Xin-Quan; Ye, Yang ; Zhu, Xing-Zu
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| 刊名 | BIOLOGICAL & PHARMACEUTICAL BULLETIN
 |
| 出版日期 | 2006-08 |
| 卷号 | 29期号:8页码:1630-1633 |
| 关键词 | paeoniflorin antinociception adenosine adenosine A(1) receptor |
| ISSN号 | 0918-6158 |
| DOI | 10.1248/bpb.29.1630 |
| 文献子类 | Article |
| 英文摘要 | The effect of paeoniflorin (PF), a major constituent isolated from Paeony radix, on N-6-Cyclopentyladenosine (CPA), a selective adenosine A(1) receptor (A(1) receptor) agonist, induced antinociception was examined in mice. In the tail-pressure test, CPA (0.05, 0.1, 0.2 mg/kg, s.c.) could induce antinociception in a dose-dependent manner. PF (5, 10, 20 mg/kg, s.c.) alone failed to exhibit any antinociceptive effect in mice; however, pretreatment of PIT (20 mg/kg, s.c.) could significantly enhance CPA-induced antinociception. Additionally, pretreatment of 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX, 0.25 mg/kg, s.c.), a selective A, receptor antagonist, could antagonize the antinociceptive effect of combining CPA with PF. Furthermore, in the competitive binding experiments, PF did not displace the binding of [H-3]-8-Cyclopentyl-1,3-dipropylxanthine ([3 HI-DPCPX) but displaced that of [H-3]-2-Chloro-N-6-cyclopentyladenosine ([H-3]-CCPA, a selective A, receptor agonist) to the membrane preparation of rat cerebral cortex. These results suggested that PF might selectively increase the binding and antinociceptive effect of CPA by binding with A, receptor. |
| WOS关键词 | WHITE ADIPOCYTES ; NERVOUS-SYSTEM ; FORMALIN TEST ; RAT ; ACTIVATION ; INCREASE ; RELEASE |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000240053500021 |
| 出版者 | PHARMACEUTICAL SOC JAPAN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273522]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhu, Xing-Zu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Da-Zhi,Zhao, Fei-Li,Liu, Jing,et al. Potentiation of adenosine A(1) receptor agonist CPA-induced antinociception by paeoniflorin in mice[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2006,29(8):1630-1633. |
| APA | Liu, Da-Zhi,Zhao, Fei-Li,Liu, Jing,Ji, Xin-Quan,Ye, Yang,&Zhu, Xing-Zu.(2006).Potentiation of adenosine A(1) receptor agonist CPA-induced antinociception by paeoniflorin in mice.BIOLOGICAL & PHARMACEUTICAL BULLETIN,29(8),1630-1633. |
| MLA | Liu, Da-Zhi,et al."Potentiation of adenosine A(1) receptor agonist CPA-induced antinociception by paeoniflorin in mice".BIOLOGICAL & PHARMACEUTICAL BULLETIN 29.8(2006):1630-1633. |
入库方式： OAI收割
来源：上海药物研究所
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