Identification and kinetics study on the transformation of mevinolin in acidic alcohol solution by high-performance liquid chromatography with photodiode array detector or mass spectrometry
文献类型：期刊论文
| 作者 | Li Yong-guo; Liu Hong ; Zhang Fang; Wang Zheng-tao; Hu Zhi-bi
|
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2006-07 |
| 卷号 | 22期号:4页码:500-504 |
| 关键词 | identification kinetic study solvates mevinolin LC-PDA-ESI-MS |
| ISSN号 | 1005-9040 |
| DOI | 10.1016/S1005-9040(06)60150-5 |
| 文献子类 | Article |
| 英文摘要 | Mevinolin is one of the earlier statin drugs which is effective for the treatment of hypercholesterolemia, as an inhibitor of the HMG-CoA reductase. The transformations of mevinolin in acidic alcohol(such as ethanol, methanol and isopropanol) solutions caused by solvent effects were revealed in the present article. The solvates, that is, mevinolinic methyl ester, mevinolinic ethyl ester and mevinolinic isopropyl ester, were identified by LC/PDA and LC/MS. The kinetics parameters of the transformations caused by solvent effects, such as the observed rate constant of mevinolin (k(obs)) the maximum concentration ( c(max)) and its corresponding maximum time ( t(max), time for the acid form to reach the maximum concentration) of mevinolinic acid, are discussed. The influencing factors, such as the kind of Solvents, the acidic concentration, the initial mevinolin concentration, and the water content as well as temperature were investigated. Two kinds of comparative-reactions, hydrolysis and alcoholysis, of mevinolin in solution were studied. This detailed study on the kinetics of mevinolin transformations is valuable and meaningful for the purification, preparation, injection manufacturing, extraction, storage, etc., of mevinolin or other similar compounds. This work provides useful information for the quality control of mevinolin and mevinolin-like drugs as well. |
| WOS关键词 | RED YEAST RICE ; BIOSYNTHESIS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| CSCD记录号 | CSCD:2631145 |
| WOS记录号 | WOS:000239983000021 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273550]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Wang Zheng-tao |
| 作者单位 | 1.Shanghai Univ Trad Chinese Med, Inst Chinese Mat Med, Key Lab Standardizat Chinese Med Minist Educ, Shanghai 201203, Peoples R China 2.Shanghai R&D Ctr Standardizat Trad Chinese Med, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Yong-guo,Liu Hong,Zhang Fang,et al. Identification and kinetics study on the transformation of mevinolin in acidic alcohol solution by high-performance liquid chromatography with photodiode array detector or mass spectrometry[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2006,22(4):500-504. |
| APA | Li Yong-guo,Liu Hong,Zhang Fang,Wang Zheng-tao,&Hu Zhi-bi.(2006).Identification and kinetics study on the transformation of mevinolin in acidic alcohol solution by high-performance liquid chromatography with photodiode array detector or mass spectrometry.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,22(4),500-504. |
| MLA | Li Yong-guo,et al."Identification and kinetics study on the transformation of mevinolin in acidic alcohol solution by high-performance liquid chromatography with photodiode array detector or mass spectrometry".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 22.4(2006):500-504. |
入库方式： OAI收割
来源：上海药物研究所
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