(5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation
文献类型：期刊论文
| 作者 | Fu, YF; Zhu, YN; Ni, J; Zhong, XG; Tang, W ; Zhou, R; Zhou, Y; Dong, JR; He, PL; Wan, H
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| 刊名 | JOURNAL OF NEUROIMMUNOLOGY
 |
| 出版日期 | 2006-06 |
| 卷号 | 175期号:1-2页码:142-151 |
| 关键词 | (5R)-5-hydroxytriptolide experimental autommume encephalomyelitis T cell cytokine |
| ISSN号 | 0165-5728 |
| DOI | 10.1016/j.jneuroim.2006.03.011 |
| 文献子类 | Article |
| 英文摘要 | A novel triptolide derivative (5R)-5-hydroxytriptolide (LLDT-8) has been shown to have potent inummosuppressive activities. Here LLDT-8 was evaluated in experimental autoimmune encephalomyelitis (EAE), the model of multiple sclerosis (MS). LLDT-8 reduced the incidence and severity of EAE, which was associated with the inhibition of the MOG 35-55 lymphocyte recall response, anti-MOG 35-55 T cell responses, interleukin (IL)-2 and interferon (IFN)-gamma production. In vitro, LLDT-8 inhibited primary T cells proliferation, division, IL-2 and IFN-gamma production stimulated with anti-CD3/28. These findings highlight the fact that LLDT-8 prevents EAE by suppressing T cell proliferation and activation, with a potential for treatment of MS. (c) 2006 Published by Elsevier B.V. |
| WOS关键词 | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS ; CENTRAL-NERVOUS-SYSTEM ; NITRIC-OXIDE SYNTHASE ; MULTIPLE-SCLEROSIS ; REDUCTASE INHIBITOR ; LYMPHOCYTE-T ; IN-VITRO ; EXPRESSION ; ATORVASTATIN ; MACROPHAGES |
| WOS研究方向 | Immunology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000238511600015 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273579]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zuo, JP |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Materia Med, Lab Immunopharmacol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Materia Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Shu Guang Hosp, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, YF,Zhu, YN,Ni, J,et al. (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation[J]. JOURNAL OF NEUROIMMUNOLOGY,2006,175(1-2):142-151. |
| APA | Fu, YF.,Zhu, YN.,Ni, J.,Zhong, XG.,Tang, W.,...&Zuo, JP.(2006).(5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation.JOURNAL OF NEUROIMMUNOLOGY,175(1-2),142-151. |
| MLA | Fu, YF,et al."(5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation".JOURNAL OF NEUROIMMUNOLOGY 175.1-2(2006):142-151. |
入库方式： OAI收割
来源：上海药物研究所
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