Selective modulation of L-type calcium current by magnesium lithospermate B in guinea-pig ventricular myocytes
文献类型：期刊论文
| 作者 | Wang, W; Hu, GY; Wang, YP
|
| 刊名 | LIFE SCIENCES
 |
| 出版日期 | 2006-05-22 |
| 卷号 | 78期号:26页码:2989-2997 |
| 关键词 | delayed rectifier K+ current inward rectifier K+ current L-type Ca2+ current magnesium lithospermate B (MLB) Na+ current ventricular myocyte |
| ISSN号 | 0024-3205 |
| DOI | 10.1016/j.lfs.2005.11.024 |
| 文献子类 | Article |
| 英文摘要 | Magnesium lithospermate B (MLB) is the main water-soluble principle of Salviae Miltiorrhizae Radix (also called as 'Danshen' in the traditional Chinese medicine) for the treatment of cardiovascular diseases. MLB was found to possess a variety of pharmacological actions. However, it is unclear whether and how MLB affects the cardiac ion channels. In the present study, the effects of MLB on the voltage-activated ionic currents were investigated in single ventricular myocytes of adult guinea pigs. MLB reversibly inhibited L-type Ca2+ current (I-Ca.L) The inhibition was use-dependent and voltage-dependent (the IC50 value of MLB was 30 mu M and 393 mu M, respectively, at the holding potential of -50 mV and -100 mV). In the presence of 100 mu M MLB, both the activation and steady-state inactivation curves of I-Ca.L were markedly shifted to hyperpolarizing membrane potentials, whereas the time course of recovery of ICa.L from inactivation was not altered. MLB up to 300 PM had no significant effect on the fast-inactivating Na+ current (I-Na), delayed rectifier K+ current (I-K) and inward rectifier K+ current (I-K1). The results suggest that the voltage-dependent Ca2+ antagonistic effect of MLB work in concert with its antioxidant action for attenuating heart ischemic injury. (c) 2005 Elsevier Inc. All rights reserved. |
| WOS关键词 | NA+ CURRENT ; RAT-HEART ; SALVIA ; CHANNELS ; BLOCK ; REPERFUSION ; ANTAGONISTS ; INHIBITION ; ISCHEMIA ; INJURY |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000237749300002 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273591]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第二研究室 |
| 通讯作者 | Wang, YP |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, W,Hu, GY,Wang, YP. Selective modulation of L-type calcium current by magnesium lithospermate B in guinea-pig ventricular myocytes[J]. LIFE SCIENCES,2006,78(26):2989-2997. |
| APA | Wang, W,Hu, GY,&Wang, YP.(2006).Selective modulation of L-type calcium current by magnesium lithospermate B in guinea-pig ventricular myocytes.LIFE SCIENCES,78(26),2989-2997. |
| MLA | Wang, W,et al."Selective modulation of L-type calcium current by magnesium lithospermate B in guinea-pig ventricular myocytes".LIFE SCIENCES 78.26(2006):2989-2997. |
入库方式： OAI收割
来源：上海药物研究所
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