Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusio'n in mice
文献类型：期刊论文
| 作者 | Wang, Zhi-fei; Tang, Li-li; Yan, Han; Wang, Yu-jun ; Tang, Xi-can
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| 刊名 | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
 |
| 出版日期 | 2006-04 |
| 卷号 | 83期号:4页码:603-611 |
| 关键词 | Huperzine A acetylcholinesterase inhibitor transient cerebral ischemia and reperfusion learning and memory nerve growth factor brain-derived neurotrophic factor transforming growth factor-beta(1) mitogen-activated protein kinase/extracellular signal-regulated kinase |
| ISSN号 | 0091-3057 |
| DOI | 10.1016/j.pbb.2006.03.027 |
| 文献子类 | Article |
| 英文摘要 | This study is to investigate the effects of huperzine A on memory deficits, neuronal damage and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice, as well as the potential downstream signaling pathway. Bilateral common carotid occlusion (BCCAo) combined with systemic hypotension induced severe memory deficits in a water maze task and neuronal degeneration in cerebral cortex and hippocampus in mice. Oral administration of huperzine A (0.2 mg/kg, once per day, started 2 days before surgery and lasted for 7 days after surgery) markedly attenuated the memory deficits and neuronal damage. Meanwhile, huperzine A significantly increased the mRNA and protein levels of NGF, BDNF and TGF-beta(1), and potentiated phosphorylation of MAPK/ERK 1/2 in both cerebral cortex and hippocampus compared with transient cerebral ischemia and reperfusion group. This study provides evidence for the protective effects of huperzine A against transient cerebral ischemia and reperfusion in mice, and suggests potentially important roles that neurotrophic factors might play in these effects. It also indicates that the MAPK/ERK pathway might be involved in the in vivo neurotrophic effects of huperzine A against transient cerebral ischemia and reperfusion. (c) 2006 Elsevier Inc. All rights reserved. |
| WOS关键词 | NERVE GROWTH-FACTOR ; NATURAL CHOLINESTERASE INHIBITOR ; REDUCES INFARCT SIZE ; GLOBAL-ISCHEMIA ; HIPPOCAMPAL-NEURONS ; FOREBRAIN ISCHEMIA ; GLUTAMATE NEUROTOXICITY ; COGNITIVE DEFICITS ; ALZHEIMERS-DISEASE ; BRAIN-DAMAGE |
| WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000238497300017 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273636]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Tang, Xi-can |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zhi-fei,Tang, Li-li,Yan, Han,et al. Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusio'n in mice[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2006,83(4):603-611. |
| APA | Wang, Zhi-fei,Tang, Li-li,Yan, Han,Wang, Yu-jun,&Tang, Xi-can.(2006).Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusio'n in mice.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,83(4),603-611. |
| MLA | Wang, Zhi-fei,et al."Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusio'n in mice".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 83.4(2006):603-611. |
入库方式： OAI收割
来源：上海药物研究所
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