S-adenosyl-L-homocysteine hydrolase inactivation curtails ovalbumin-induced immune responses
文献类型：期刊论文
| 作者 | Fu, YF; Wang, JX; Zhao, Y; Yang, Y ; Tang, W; Ni, J; Zhu, YN; Zhou, R; He, PL; Li, C
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| 刊名 | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
 |
| 出版日期 | 2006-03 |
| 卷号 | 316期号:3页码:1229-1237 |
| ISSN号 | 0022-3565 |
| DOI | 10.1124/jpet.105.093369 |
| 文献子类 | Article |
| 英文摘要 | The reversible S-adenosyl-L-homocysteine (AdoHcy) hydrolase inhibitor methyl 4-(adenin-9-yl)-2-hydroxybutanoate (DZ2002) suppresses macrophage activation and function. The effects of DZ2002 on T cell function, however, are still unclear. Here, we examined whether DZ2002 alters type 1 helper T cell (Th1) and/or type 2 helper T cell (Th2) immune responses, and whether these effects are associated with both the inhibition of AdoHcy hydrolase and intracellular elevation of endogenous AdoHcy. Male C57BL/6 mice immunized with ovalbumin (OVA) were treated with DZ2002 (1, 5, and 25 mg/kg/day) after which lymphocyte proliferation, cytokine production, and IgG responses to OVA were monitored. Administration of DZ2002 dose dependently suppressed OVA-specific lymphocyte proliferation and anti-OVA IgG production compared with controls. Interleukin (IL)-2 and interferon (IFN)-gamma as well as anti-OVA IgG2a and IgG3, indicators of Th1 immune responses, were markedly decreased in mice treated with DZ2002, whereas IL-4 and anti-OVA IgG1, indicators of Th2 immune responses, were only mildly suppressed. AdoHcy hydrolase activity in spleens of DZ2002-treated mice was substantially blocked, and not surprisingly, AdoHcy levels were significantly elevated compared with controls. Finally, similar immunosuppressive effects were also observed in mice treated with AdoHcy. These data strongly indicate that DZ2002 suppresses antigen-induced specific immune responses, particularly Th1 responses, through inhibition of AdoHcy hydrolase and elevation of endogenous AdoHcy. |
| WOS关键词 | T-CELL-ACTIVATION ; IN-VIVO ; ASYMMETRIC DIMETHYLARGININE ; ARGININE METHYLATION ; INDUCED ARTHRITIS ; GENE-EXPRESSION ; LYMPHOID-CELLS ; BISPHENOL-A ; RAT-BRAIN ; INHIBITOR |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000235476000032 |
| 出版者 | AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273662]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zuo, JP |
| 作者单位 | 1.Diazyme Labs Div Gen Atom, San Diego, CA USA 2.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, Grad Sch,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Grad Sch,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Metab & Pharmacokinet Res, Grad Sch,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China 5.Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, YF,Wang, JX,Zhao, Y,et al. S-adenosyl-L-homocysteine hydrolase inactivation curtails ovalbumin-induced immune responses[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,2006,316(3):1229-1237. |
| APA | Fu, YF.,Wang, JX.,Zhao, Y.,Yang, Y.,Tang, W.,...&Zuo, JP.(2006).S-adenosyl-L-homocysteine hydrolase inactivation curtails ovalbumin-induced immune responses.JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,316(3),1229-1237. |
| MLA | Fu, YF,et al."S-adenosyl-L-homocysteine hydrolase inactivation curtails ovalbumin-induced immune responses".JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 316.3(2006):1229-1237. |
入库方式： OAI收割
来源：上海药物研究所
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