Liquid chromatography-tandem mass spectrometry method for the quantification of deglymidodrine in human plasma
文献类型：期刊论文
| 作者 | Jia, JY; Liu, GY; Li, SJ; Li, XC; Yuan, WF; Yu, C; Wang, YP
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| 刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
 |
| 出版日期 | 2006-02-24 |
| 卷号 | 40期号:3页码:715-719 |
| 关键词 | deglymidodrine midodrine LC-MS/MS pharmacokinetic plasma |
| ISSN号 | 0731-7085 |
| DOI | 10.1016/j.jpba.2005.08.015 |
| 文献子类 | Article |
| 英文摘要 | A simple, rapid and sensitive liquid chromatography-tandem mass spectrometry method was developed for quantification of deglymidodrine in human plasma. The plasma samples were pretreated by protein precipitation with trichloroacetate. The chromatographic separation was performed on reversed phase Aquasil C-18 column, and the plasma extraction was eluted with a mobile phase solution consisting of acetonitrile (containing 0.02% formic acid) and water (containing 0.02% formic acid). The molecular ion of analyte was detected in positive ionization by multiple reaction monitoring. The mass transitions of m/z 198.4 -> 148.1 and m/z 212.4 -> 162.3 were used for detection of deglymidodrine and its internal standard, respectively. The assay exhibited linear ranges from 0.25 to 32 ng/ml for the analyte in human plasma. Acceptable precision and accuracy were obtained for concentrations of quality control (QC) samples. The proposed method has been successfully used to analyze human plasma samples for application in oral pharmacokinetic study. (c) 2005 Elsevier B.V. All rights reserved. |
| WOS关键词 | NEUROGENIC ORTHOSTATIC HYPOTENSION ; MIDODRINE ; EFFICACY ; THERAPY ; SYNCOPE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000235821100027 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273664]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yu, C |
| 作者单位 | 1.Shanghai Xuhui Cent Hosp, Cent Lab, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jia, JY,Liu, GY,Li, SJ,et al. Liquid chromatography-tandem mass spectrometry method for the quantification of deglymidodrine in human plasma[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2006,40(3):715-719. |
| APA | Jia, JY.,Liu, GY.,Li, SJ.,Li, XC.,Yuan, WF.,...&Wang, YP.(2006).Liquid chromatography-tandem mass spectrometry method for the quantification of deglymidodrine in human plasma.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,40(3),715-719. |
| MLA | Jia, JY,et al."Liquid chromatography-tandem mass spectrometry method for the quantification of deglymidodrine in human plasma".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 40.3(2006):715-719. |
入库方式： OAI收割
来源：上海药物研究所
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